Systemic coordination of stress responses by insulin signaling
Description: Regulation of Insulin signaling activity by stress signaling is an important process that allows adaptation to environmentally stressful conditions. At the same time, this antagonism promotes insulin signaling defects observed in age-related metabolic diseases. The proposed project seeks to characterize the signaling interactions that govern metabolic and tissue homeostasis systemically and test whether such interaction influence metabolic health, tissue maintenance and longevity in the fly. The studies will be performed using Drosophila, a genetically accessible model organism with a long history of significant contributions to biomedical research.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2006-06-01
End date: 2016-02-29
Investigator: HEINRICH JASPER
Institution: BUCK INSTITUTE FOR RESEARCH ON AGING
Funded outputs count: 41
Funder award ID: R01AG028127
OpenAlex ID: G3369422997