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MR & Optical Diagnosis of Mitochondrial Metabolism and Dysfunction

Funding type: research
Funder scheme: R01
Start date: 1993-02-01
End date: 2013-07-31
Investigator: KEVIN E CONLEY
Institution: UNIVERSITY OF WASHINGTON
Funded outputs count: 69
Funder award ID: R01AR041928
OpenAlex ID: G6434486400
Mitochondrial NAD(P)H In vivo: Identifying Natural Indicators of Oxidative Phosphorylation in the 31P Magnetic Resonance Spectrum
2016 · Kevin E. Conley, Amir S. Ali, et al. · Frontiers in Physiology · 22
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Mitochondria to motion: optimizing oxidative phosphorylation to improve exercise performance
2016 · Kevin E. Conley · Journal of Experimental Biology · 85
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Muscle force, work and cost: a novel technique to revisit the Fenn Effect
2015 · Justus O. Ortega, Stan L. Lindstedt, et al. · Journal of Experimental Biology · 52
In Vivo Metabolic Spectroscopy Identifies Deficits in Mitochondrial Quality and Capacity in Aging Skeletal Muscle
2014 · D J Marcinek, K E Conley · Clinical Pharmacology & Therapeutics · 5
In vivo absolute quantification for mouse muscle metabolites using an inductively coupled synthetic signal injection method and newly developed 1H/31P dual tuned probe
2014 · Donghoon Lee, Kenneth Marro, et al. · Journal of Magnetic Resonance Imaging
Neurochemical correlates of caudate atrophy in Huntington's disease
2014 · Jeannie M. Padowski, Kurt E. Weaver, et al. · Movement Disorders · 26
Multiparameter MRI analysis of the time course of induced muscle damage and regeneration
2013 · Shu Feng, Daniel Chen, et al. · Journal of Magnetic Resonance Imaging · 14
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Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism
2013 · Zhenji Gan, John Rumsey, et al. · Journal of Clinical Investigation · 198
Elevated energy coupling and aerobic capacity improves exercise performance in endurance‐trained elderly subjects
2012 · Kevin E. Conley, Sharon A. Jubrias, et al. · Experimental Physiology · 32
Higher Mitochondrial Respiration and Uncoupling with Reduced Electron Transport Chain Contentin Vivoin Muscle of Sedentary Versus Active Subjects
2012 · Kevin E. Conley, Catherine E. Amara, et al. · The Journal of Clinical Endocrinology & Metabolism · 35
Exercise efficiency is reduced by mitochondrial uncoupling in the elderly
2012 · Kevin E. Conley, Sharon A. Jubrias, et al. · Experimental Physiology · 78
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Skeletal Muscle Mitochondrial Energetics Are Associated With Maximal Aerobic Capacity and Walking Speed in Older Adults
2012 · Paul M. Coen, Sharon A. Jubrias, et al. · The Journals of Gerontology Series A · 323
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Ectopic Lipid Accumulation and Reduced Glucose Tolerance in Elderly Adults Are Accompanied by Altered Skeletal Muscle Mitochondrial Activity
2011 · Darcy L. Johannsen, Kevin E. Conley, et al. · The Journal of Clinical Endocrinology & Metabolism · 107
High efficiency in human muscle: an anomaly and an opportunity?
2011 · Frank E. Nelson, Justus D. Ortega, et al. · Journal of Experimental Biology · 20
Lazy or old: mitochondria decline in vivo in human muscle similarly with inactivity and age
2011 · kevin Conley, Sharon Jubrias, et al. · The FASEB Journal
Immunity and AAV-Mediated Gene Therapy for Muscular Dystrophies in Large Animal Models and Human Trials
2011 · Zejing Wang, Stephen J. Tapscott, et al. · Frontiers in Microbiology · 53
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Defining the limits to efficiency in human muscle in vivo
2010 · Frank Edward Nelson, Kevin Conley, et al. · The FASEB Journal
Lactic acidosis in vivo: testing the link between lactate generation and H+ accumulation in ischemic mouse muscle
2010 · David J. Marcinek, Martin J. Kushmerick, et al. · Journal of Applied Physiology · 78
Immune Responses to AAV in Canine Muscle Monitored by Cellular Assays and Noninvasive Imaging
2009 · Zejing Wang, Rainer Storb, et al. · Molecular Therapy · 41
Noninvasive In Vivo Small Animal MRI and MRS: Basic Experimental Procedures
2009 · Donghoon Lee, David Marcinek · Journal of Visualized Experiments · 9
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Mitochondrial function in vivo: Spectroscopy provides window on cellular energetics
2008 · Catherine E. Amara, David J. Marcinek, et al. · Methods · 65
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Tail morphology in the Western Diamond‐backed rattlesnake, Crotalus atrox
2008 · Alan H. Savitzky, Brad R. Moon · Journal of Morphology · 11
Contraction coupling efficiency of human first dorsal interosseous muscle
2008 · Sharon A. Jubrias, Nina K. Vollestad, et al. · The Journal of Physiology · 36
Mitochondrial dysfunction and age
2007 · Kevin E Conley, David J Marcinek, et al. · Current Opinion in Clinical Nutrition & Metabolic Care · 106
Wavelength Shift Analysis: A Simple Method to Determine the Contribution of Hemoglobin and Myoglobin to In Vivo Optical Spectra
2007 · David J. Marcinek, Catherine E. Amara, et al. · Applied Spectroscopy · 58
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