Regeneration and plasticity of lymphatic vasculature
Description: Lymphatic vasculature forms complex networks essential for the function of vertebrate tissues and organs. The cellular and molecular mechanisms that control embryonic development of lymphatics are well characterised. By contrast, lymphatic regeneration has gone largely unstudied because mammals cannot regenerate entire lymphatic networks. We have discovered that zebrafish lymphatics regenerate from near complete loss to form extensive vessel networks. This project will define mechanisms of lymphatic regeneration for the first time. It will generate fundamental knowledge and open up a new field of investigation. By expanding regenerative biology, this project will have major outcomes and implications in tissue engineering, repair and aging.
Funder: Australian Research Council
Amount: A$978,400
Funding type: research
Funder scheme: Discovery Projects
Start date: 2026-01-01
End date: 2029-12-31
Investigator: Benjamin Hogan
Institution: The University of Melbourne
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 0
Funder award ID: DP260104017
OpenAlex ID: G3311456342