Blood biomarker for differentiating geriatric depression from Alzheimer's disease
Description: To search for blood biomarkers to differentiate between geriatric depression (GD) and Alzheimer's disease (AD), we analyzed human blood, hippocampus and blood of AD model mice. We identified altered gene expression of MEF2C, Ghrelin, and PICALM in the blood of AD patients. On the other hand, PICALM was not altered in GD, which may be a useful marker for differentiation. In the microarray study using model mice, the human blood biomarkers that we have identified were also confirmed in mouse blood. We found that CDKN2A, which is involved in cellular senescence, was significantly altered in both blood and hippocampal tissues, and CDKN2A was also not altered in GD, which may be useful for differentiating AD from GD (submitted).
Amount: ¥4,550,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Junichi Iga
Institution: Ehime University
Funded outputs count: 26
Funder award ID: 18K07564
OpenAlex ID: G331330169