Cellular and Molecular Consequences of Respiratory Chain Defects in Neurons
Description: Mitochondrial diseases affect mostly brain and muscles. Many age-related neurodegenerative disorders are also believed to be caused by mitochondrial dysfunction. Mitochondria are unique because they have their own DNA (mtDNA). In this project we will study the accumulation and functional consequences of deletions and point mutations in the mtDNA in the central nervous system, both of which have been shown to cause mitochondrial diseases and neurodegeneration.
Funding type: research
Funder scheme: R01
Start date: 2012-05-15
End date: 2025-03-31
Investigator: CARLOS TORRES MORAES
Institution: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 66
Funder award ID: R01NS079965
OpenAlex ID: G5175993970