Mechanistically linking AMD, glycemic index and protein homeostasis
Description: We will address the major NIH objective of understanding the molecular and biochemical bases for AMD, characterizing environmental effects on its etiology, and developing new treatments and preventative interventions by substantiating recent epidemiologic reports that indicate that eating lower glycemic index diets diminishes risk for early AMD, elucidating the mechanism of this health benefit, and trying new drugs to mimic what we think are the effects of consuming the lower GI diets. The mechanistic studies will also inform about the design of novel nutraceuticals or new drugs which capture the salutary effects of consuming lower GI diets to diminish the risk for AMD. The carbohydrate content of our diets has doubled in the last 30 years and most of that is rapidly degraded high glycemic index carbohydrate. The data will also help diminish risk for type 2 diabetes and CVD because the risk for these diseases is also related to dietary glycemic index.
Funder: National Eye Institute
Funding type: research
Funder scheme: R01
Start date: 2011-09-30
End date: 2016-08-31
Investigator: ALLEN TAYLOR
Institution: TUFTS UNIVERSITY BOSTON
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Funded outputs count: 44
Funder award ID: R01EY021212
OpenAlex ID: G1278738366