The role of somatic mutation in neurodegenerative disease
Description: The aim of this proposal is to characterize multiple forms of somatic mutations in Alzheimer’s Disease and Ataxia-Telangiectasia, two neurodegenerative disorders that do not have effective treatments, by using single-cell genomic analysis. This project will not only enable a better understanding of the role of somatic mutations in Alzheimer’s Disease and Ataxia-Telangiectasia but also provide a framework for single-cell genomic analysis that can be applied to other neurodevelopmental and neurodegenerative diseases.
Funder: National Institute on Aging
Funding type: career_development
Funder scheme: K01
Start date: 2016-08-01
End date: 2021-04-30
Investigator: EUNJUNG ALICE LEE
Institution: BOSTON CHILDREN'S HOSPITAL
Funded outputs count: 26
Funder award ID: K01AG051791
OpenAlex ID: G5181568931