Roles of fast-type skeletal muscle-specific microRNA
Description: We clarified relationship between miR-196a and myosin heavy chain (MyHC) isoform expression in bovine masseter (MS), diaphragm (DP), semispinalis (SP), semitendinosus (ST), and longissimus dorci (LD) muscles, to investigate roles of miR-196a in bovine muscle type specification. The quantitative RT-PCR results showed that miR-196a is exclusively expressed in MyHC-2x isoform-abundant ST and LD muscles compared to the others (P < 0.001). The expression of miR-196a was correlated with those of MyHC-2x isoform (r = 0.738) and MyHC-slow (r = -0.764). These results revealed that miR-196a expression is highly associated with muscle type that is determined by MyHC isoform expression in bovine skeletal muscles.
Amount: ¥5,070,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2015-04-01
End date: 2019-03-31
Investigator: Susumu MUROYA
Institution: National Agriculture and Food Research Organization
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 5
Funder award ID: 15K07775
OpenAlex ID: G3334256969