Understanding of the aging process and neuronal tissue robustness
Description: Why are so many neurodegenerative diseases late onset? In this study, we used Drosophila as an experimental model of aging, which has a shorter lifespan than mammals. The purpose of this study was to develop a new model of neurodegeneration to evaluate the robustness of traumatic brain injury (TBI) and to clarify the molecular mechanism of aging-induced robustness loss. The results showed that TBI treatment of Drosophila caused an abnormal activation of innate immunity in aged individuals compared to young ones. In addition, minocycline, which has an inhibitory effect on neurodegeneration, was found to be ineffective in aged flies, suggesting that the excessive activation of innate immunity is also the underlying factor.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Rikako SANUKI
Institution: Kyoto Institute of Technology
Funded outputs count: 4
Funder award ID: 18K06485
OpenAlex ID: G3335039337