Elucidation and application to treatment of the mechanism of intestinal regeneration dysfunction cased by high-fat diet intake and psychological stress ical stress and its application to treatment
Description: Treatment with LXR agonists in intestinal stem cells affected neither inflammasome activation nor differentiation into intestinal epithelial cells. It has been revealed that oxidative stress induces inflammasome activation. Treatemnt with molecular hydrogen, a potent antioxidant, improved intestinal regeneration and supressed gut injury in high fat diet-loaded senescence- accelerated mice prone 8 (SAMP8 mice).
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2022-03-31
Investigator: Sayaka Nomura
Institution: National Defense Medical College
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Funded outputs count: 4
Funder award ID: 18K11120
OpenAlex ID: G333529558