The role of epigenetics in age-related cognitive decline and Alzheimer’s disease
Description: PROJECT NARRATIVE The remarkable 30-year increase in life expectancy is a great achievement, but its success has brought an increase in age-related disorders, which carry a heavy social and economic burden. Brain aging disorders represent one of the major causes of disability and dependency, with Alzheimer's disease at the forefront. Emerging evidence links age-related gene expression changes with alterations in how our DNA is packed; thus, I will use a novel mouse called “ICE” (inducible changes in the epigenome) to test whether alterations in DNA packaging result in age-related cognitive decline and Alzheimer's disease pathology, and if these changes are preventable or even reversible.
Funder: National Institute on Aging
Funding type: career_development
Funder scheme: K99
Start date: 2017-04-01
End date: 2020-03-31
Investigator: JAIME MARIE ROSS
Institution: HARVARD MEDICAL SCHOOL
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 6
Funder award ID: K99AG055683
OpenAlex ID: G2988712599