Balance of Thymic Negative Selection vs. Treg Cell Generation in the Elderly
Description: PUBLIC HEALTH RELEVANCE: Relevance to public health: Age-related chronic inflammatory diseases can be tracked to thymic involution-released self-reactive T cells, which should be balanced by FoxP3+ regulatory T cells, whereas the mechanistic balance is currently unknown. By determining the mechanism of the balance and exploring a potential rejuvenation strategy to reach a rebalance, the rejuvenation process to prevent and cure chronic inflammatory diseases in the elderly will be eventually achieved. .
Funding type: research
Funder scheme: R01
Start date: 2015-12-01
End date: 2021-11-30
Investigator: DONG-MING SU
Institution: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Funded outputs count: 11
Funder award ID: R01AI121147
OpenAlex ID: G7987257135