Building on GWAS for NHLBI-disease: the CHARGE consortium
Description: Project Narrative: "Building on GWAS for NHLBI-diseases: the U.S. CHARGE consortium" will leverage existing resources to identify genes underlying genome-wide significant and well-replicated GWAS findings for heart, lung and blood diseases. We will carry-out targeted resequencing (400 cases and 400 controls) in 60 genomic regions influencing 15 phenotypes. Second, we will take a first step toward illuminating the dark matter of unaccounted-for genetic variance for one model phenotype (i.e. HDL cholesterol) by whole genome sequencing of 230 African-Americans selected from the top and bottom 10% of the HDL-cholesterol distribution.
Funding type: research
Funder scheme: RC2
Start date: 2009-09-30
End date: 2012-09-30
Investigator: ERIC A. BOERWINKLE
Institution: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
Funded outputs count: 295
Funder award ID: RC2HL102419
OpenAlex ID: G8894965210