Award

3/22 DPPOS Limited Competition for the Continuation of the Diabetes Prevention Program Outcomes Study (DPPOS) – Clinical Center

Description: The DPPOS cohort is broadly representative of the current population with pre-diabetes and Type 2 diabetes (T2D), which affect >110,000,000 individuals in the U.S. with the total cost of diabetes currently estimated at $327 billion, and provides 24 years of information on their course and complications. Understanding the effects of preventing or delaying T2D on human disease, the potential long-term benefits of lifestyle intervention and metformin, one of the most commonly used medications in the world, and the clinical course of pre-diabetes and T2D is critical if we are to apply prevention and treatment methods effectively and efficiently. We will perform new analyses to characterize the heterogeneous course of dysglycemia and its long- term complications and factors that define susceptibility or resistance to diabetes, its complications, common chronic conditions of aging, and explore the factors associated with participant retention, adherence to the protocol and completion of measurements.
Funding type: cooperative_agreement
Funder scheme: U01
Start date: 1994-08-15
End date: 2022-08-31
Investigator: KEVIN J. FURLONG
Institution: THOMAS JEFFERSON UNIVERSITY
Funded outputs count: 70
Funder award ID: U01DK048468
OpenAlex ID: G7989041750
2026 · Justin B. Echouffo‐Tcheugui, Xun Liu, et al. · Diabetes Obesity and Metabolism
2026 · Marcel E. Salive, Ashley H. Tjaden, et al. · JAMA · 5
2024 · William H. Herman, Shihchen Kuo, et al. · Diabetes Obesity and Metabolism · 1
2024 · Allison L.B. Shapiro, Ashley H. Tjaden, et al. · Journal of Diabetes and its Complications · 2
2023 · Yooni A. Blair, Lindsay Doherty, et al. · Journal of Diabetes and its Complications · 5
2023 · Kishore M. Gadde, Xiaoyan Yin, et al. · Journal of the American Heart Association · 8
2023 · Mark E. Molitch, Mark Tripputi, et al. · Journal of Diabetes and its Complications · 5
2022 · Amitha Domalpally, Samuel A. Whittier, et al. · JAMA Ophthalmology · 25
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