Defining the relative roles of pre- and post-synaptic events in the initiation and progression of sarcopenia
Description: PUBLIC HEALTH RELEVANCE: Age-related declines in muscle mass and function are important contributors to the major public health problem of frailty, which significantly increases the risk for debilitating falls and reduces mobility, independence, and quality of life among the elderly. The lack of understanding of mechanisms of muscle fiber weakness and loss represents a critical barrier to progress toward the development of successful interventions for ameliorating physical frailty and thereby improving quality of life for the elderly. Thus, the public health relevance of the present project lies in the increased understanding of the mechanisms underlying muscle loss and weakness that is critical for identifying therapeutic targets with maximum effectiveness.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2016-04-15
End date: 2023-03-31
Investigator: SUSAN V BROOKS
Institution: UNIVERSITY OF MICHIGAN AT ANN ARBOR
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 33
Funder award ID: R01AG050676
OpenAlex ID: G8394095177