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Thioredoxin interacting protein is critical for development of early diabetic retinopathy

Description: Project Narrative: Diabetic retinopathy (DR) is a severe complication of the eyes leading to blindness; yet there is no cure. Our laboratory is exploring ways to prevent DR by targeting a protein called thioredoxin-interacting protein (TXNIP), its downstream mediators and mitophagy, a process for removing damaged mitochondria, which is an organelle for energy production in cells. We propose that TXNIP-mediated gene therapy is a potential approach for treating DR.
Funding type: research
Funder scheme: R01
Start date: 2014-12-02
End date: 2022-07-29
Investigator: LALIT SINGH PUKHRAMBAM
Institution: WAYNE STATE UNIVERSITY
Funded outputs count: 13
Funder award ID: R01EY023992
OpenAlex ID: G6451740501
Differential Effects of Cytopathic Hypoxia on Human Retinal Endothelial Cellular Behavior: Implication for Ischemic Retinopathies
2022 · Shaimaa El-tanani, Thangal Yumnamcha, et al. · International Journal of Molecular Sciences · 10
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Potential Combination Drug Therapy to Prevent Redox Stress and Mitophagy Dysregulation in Retinal Müller Cells under High Glucose Conditions: Implications for Diabetic Retinopathy
2021 · Lalit Pukhrambam Singh, Takhellambam S. Devi · Diseases · 21
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"Mitophagy, Ferritinophagy and Ferroptosis in Retinal Pigment Epithelial Cells Under High Glucose Conditions: Implications for Diabetic Retinopathy and Age-Related Retinal Diseases"
2021 · Lalit Pukhrambam Singh, Thangal Yumnamcha, et al. · JOJ Ophthalmology · 42
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Relative Contribution of Different Mitochondrial Oxidative Phosphorylation Components to the Retinal Pigment Epithelium Barrier Function: Implications for RPE-Related Retinal Diseases
2021 · Michael H. Guerra, Thangal Yumnamcha, et al. · International Journal of Molecular Sciences · 11
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Metabolic Dysregulation and Neurovascular Dysfunction in Diabetic Retinopathy
2020 · Thangal Yumnamcha, Michael Guerra, et al. · Antioxidants · 102
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Auranofin Mediates Mitochondrial Dysregulation and Inflammatory Cell Death in Human Retinal Pigment Epithelial Cells: Implications of Retinal Neurodegenerative Diseases
2019 · Thangal Yumnamcha, Takhellembam Swornalata Devi, et al. · Frontiers in Neuroscience · 92
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TXNIP mediates high glucose-induced mitophagic flux and lysosome enlargement in human retinal pigment epithelial cells
2019 · Takhellambam S. Devi, Thangal Yumnamcha, et al. · Biology Open · 55
Gene and Tissue Engineering For the Treatment of Diabetes and Its Retinal Complications: The Use of Nucleic Acid Constructs Bearing A TXNIP Gene Promoter
2018 · Lalit P Singh · Current Trends in Biomedical Engineering & Biosciences · 4
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Potentials of Gene Therapy for Diabetic Retinopathy: The Use of Nucleic Acid Constructs Containing a TXNIP Promoter
2018 · Lalit PS · Open Access Journal of Ophthalmology · 5
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Mitophagic Flux Deregulation, Lysosomal Destabilization and NLRP3 Inflammasome Activation in Diabetic Retinopathy: Potentials of Gene Therapy Targeting TXNIP and The Redox System.
2018 · Lalit Pukhrambam Singh, Thangal Yumnamcha, et al. · PubMed · 12
The Role of Txnip in Mitophagy Dysregulation and Inflammasome Activation in Diabetic Retinopathy: A New Perspective
2017 · Lalit P Singh · JOJ Ophthalmology · 58
TXNIP regulates mitophagy in retinal Müller cells under high-glucose conditions: implications for diabetic retinopathy
2017 · Takhellambam Swornalata Devi, Mallika Somayajulu, et al. · Cell Death and Disease · 122
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Genetic and epigenetic modifications in the pathogenesis of diabetic retinopathy: a molecular link to regulate gene expression
2016 · Priya Pradhan, Nisha Upadhyay, et al. · New Frontiers in Ophthalmology · 30
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