Omics Profiles of Fecal Microbiota Change in Irritable Bowel Syndrome Patients with Diarrhea and Symptom Exacerbation
Description: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction. However, the role of gastrointestinal microbiota during IBS symptom exacerbation remains unclear. We tested the hypothesis that the fecal microbial composition are altered during the exacerbation of IBS symptoms. Fecal samples were collected from 43 men with IBS with diarrhea (IBS-D) and 40 healthy control (HC) men. Samples in the IBS-D patients were also collected during symptom exacerbation. The composition of the fecal microbiota was determined by analyzing the 16S rRNA gene and metabolites.The fecal microbiota during IBS symptom exacerbation exhibited significant differences in the phylogenic pattern and short-chain fatty acid compared to without symptom exacerbation. Although there were no significant differences in the phylogenic pattern of fecal microbiota abundance between HCs and IBS-D patients.Our findings suggest that fecal microbiome are altered in IBS-D patients during exacerbation of symptoms.
Amount: ¥4,290,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2017-04-01
End date: 2022-03-31
Investigator: Yukari Tanaka
Institution: Tohoku University
Funded outputs count: 5
Funder award ID: 17K17584
OpenAlex ID: G348162358