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Study on the mechanism of structural and tensional memory of cells

Description: 血管や骨などの生体組織は力の変化に応じて細胞が応答し「リモデリング」する.最近,申請者らは,細胞には,内部構造や発生する張力を効率良く再現させる「構造と力の記憶」が備わる可能性に気付いた.そこで.本研究では,細胞の内部構造をバラバラにした後,その構造や張力が再現する過程を詳しく調べる.そして,細胞や組織全体が如何にして「記憶の維持」と「記憶のリセット」を切り替えているのか明らかにする.
Amount: ¥6,500,000
Funding type: research
Funder scheme: Grant-in-Aid for Challenging Research (Exploratory)
Start date: 2019-06-28
End date: 2021-03-31
Investigator: Kazuaki Nagayama
Institution: Ibaraki University
Funded outputs count: 8
Funder award ID: 19K22944
OpenAlex ID: G3483125552
2020 · Kazuaki NAGAYAMA, Kenzo NOGAMI, et al. · Journal of the Japan Society for Precision Engineering · 1
2020 · Kazuaki Nagayama, Shigeaki Ohata, et al. · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · 18
2020 · Kazuaki Nagayama, Kouhei Nishimiya · Bio-Medical Materials and Engineering · 14
2020 · Yoshito Yamashiro, Bui Quoc Thang, et al. · Proceedings of the National Academy of Sciences · 182
2019 · Kazuaki Nagayama, Tomohiro Fukuei · Biomechanics and Modeling in Mechanobiology · 17
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