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R01DK103046

Funded outputs count: 41
Funder award ID: R01DK103046
OpenAlex ID: G349855248
Loss or gain of function: The functional complexity of the PNPLA3 I148M variant
2025 · Sepideh Mikaeeli, David E. Cohen · Journal of Hepatology · 4
Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog
2024 · Jaclyn Weinberg, Ken H. Liu, et al. · Journal of Biological Chemistry · 5
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ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress
2024 · Xu Xu, Arturo Mendoza, et al. · Science Signaling · 2
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Activity and phosphatidylcholine transfer protein interactions of skeletal muscle thioesterase Them2 enable hepatic steatosis and insulin resistance
2024 · Yang Xie, Xu Liu, et al. · Journal of Biological Chemistry · 1
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Structure, function, and lipid sensing activity in the thioesterase superfamily
2024 · Molly Little, Eric A. Ortlund · Biochemical Society Transactions · 7
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Pharmacologic inhibition of lipogenesis for the treatment of NAFLD
2023 · William P. Esler, David E. Cohen · Journal of Hepatology · 111
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High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease
2023 · Christopher S. Krumm, Renée S. Landzberg, et al. · Molecular Metabolism · 4
Pathophysiology updates: gastroduodenal injury and repair mechanisms
2023 · Susan J. Hagen · Current Opinion in Gastroenterology · 3
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Neuroendocrine mechanism of gastric acid secretion: Historical perspectives and recent developments in physiology and pharmacology
2023 · Duan Chen, Susan J. Hagen, et al. · Journal of Neuroendocrinology · 22
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Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice
2023 · Samuel A. Druzak, Matteo Tardelli, et al. · Nature Communications · 11
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Acyl-CoA thioesterase 12 suppresses YAP-mediated hepatocarcinogenesis by limiting glycerolipid biosynthesis
2023 · Haiyue He, Akiko Sugiyama, et al. · Cancer Letters · 13
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes
2023 · Alfonso Rubio-Navarro, Nicolás Gómez-Banoy, et al. · Nature Cell Biology · 71
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Gastroduodenal injury and repair: novel targets for therapeutic intervention
2022 · Susan J. Hagen · Current Opinion in Gastroenterology · 4
Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice
2022 · Mohammad Kabbani, Eleftherios Michailidis, et al. · Cell Reports · 34
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Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy
2022 · Stefan Tholen, Roma Patel, et al. · Cell Reports · 24
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Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP
2021 · Arturo Mendoza, Catherine Tang, et al. · Science Signaling · 37
Mucosal defense: gastroduodenal injury and repair mechanisms
2021 · Susan J. Hagen · Current Opinion in Gastroenterology · 15
Up‐regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice
2021 · Norihiro Imai, Hayley T. Nicholls, et al. · Hepatology · 11
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Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice
2021 · Yue Li, Norihiro Imai, et al. · Nature Communications · 7
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Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice
2021 · Christopher S. Krumm, Xu Xu, et al. · Journal of Biological Chemistry · 11
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Targeting Them1 for the Management of Obesity‐Related Disorders
2021 · Christopher Krumm, Lavoisier Ramos‐Espiritu, et al. · The FASEB Journal
Claudin-18 Loss Alters Transcellular Chloride Flux but not Tight Junction Ion Selectivity in Gastric Epithelial Cells
2020 · Tyler J. Caron, Kathleen E. Scott, et al. · Cellular and Molecular Gastroenterology and Hepatology · 12
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Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine
2020 · Matthew C. Tillman, Norihiro Imai, et al. · Proceedings of the National Academy of Sciences · 25
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Dissociation of Adaptive Thermogenesis from Glucose Homeostasis in Microbiome-Deficient Mice
2020 · Tibor I. Krisko, Hayley T. Nicholls, et al. · Cell Metabolism · 77
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Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins
2019 · Samir Softic, Jesse G. Meyer, et al. · Cell Metabolism · 225
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