Get started
Award

Aging-associated dysregulation of the hypoxia pathway limits skeletal muscle regeneration

Description: Project Narrative Aging results in a severe decline of skeletal muscle regenerative potential, which manifests clinically as decreased muscle mass, impaired function, and a loss of independence. The proposed study will advance our understanding of how the hypoxia signaling pathway becomes dysregulated in aging and its impact on muscle regeneration. Furthermore, it will evaluate whether restoring hypoxia signaling improves skeletal muscle regenerative potential and maintains muscle mass in a murine model of aging.
Funding type: career_development
Funder scheme: K76
Start date: 2018-08-01
End date: 2023-05-31
Investigator: INDRANIL SINHA
Institution: BRIGHAM AND WOMEN'S HOSPITAL
Funded outputs count: 13
Funder award ID: K76AG059996
OpenAlex ID: G7904598772
The Role of Hypoxia and Hypoxia Signaling in Skeletal Muscle Physiology
2023 · Yori Endo, Christina Zhu, et al. · Advanced Biology · 10
Mechanisms of Skeletal Muscle Atrophy and Molecular Circuitry of Stem Cell Fate in Skeletal Muscle Regeneration and Aging
2023 · Sue C Bodine, Indranil Sinha, et al. · The Journals of Gerontology Series A · 45
PDF
VEGFA Promotes Skeletal Muscle Regeneration in Aging
2023 · Yori Endo, Charles D. Hwang, et al. · Advanced Biology · 20
PDF
Exercise-induced gene expression changes in skeletal muscle of old mice
2021 · Yori Endo, Yuteng Zhang, et al. · Genomics · 20
Miniaturized Needle Array‐Mediated Drug Delivery Accelerates Wound Healing
2021 · Mohamadmahdi Samandari, Fariba Aghabaglou, et al. · Advanced Healthcare Materials · 47
Muscle Cryoinjury and Quantification of Regenerating Myofibers in Mice
2021 · Yori Endo, Mehran Karvar, et al. · BIO-PROTOCOL · 8
PDF
Loss of ARNT in skeletal muscle limits muscle regeneration in aging
2020 · Yori Endo, Kodi Baldino, et al. · The FASEB Journal · 18
PDF
Optimizing Skeletal Muscle Anabolic Response to Resistance Training in Aging
2020 · Yori Endo, Atousa Nourmahnad, et al. · Frontiers in Physiology · 69
PDF
Adult-Onset Myopathy with Constitutive Activation of Akt following the Loss of hnRNP-U
2020 · Debalina Bagchi, Benjamin D. Mason, et al. · iScience · 10
PDF
A porous collagen‐GAG scaffold promotes muscle regeneration following volumetric muscle loss injury
2019 · Adriana C. Panayi, Lucindi Smit, et al. · Wound Repair and Regeneration · 28
Implications of Aging in Plastic Surgery
2019 · Danny S. Roh, Adriana C. Panayi, et al. · Plastic & Reconstructive Surgery Global Open · 30
Nuclear localized Akt limits skeletal muscle derived fibrotic signaling
2018 · Eleonora Guadagnin, Debalina Bagchi, et al. · Biochemical and Biophysical Research Communications
Impact of frailty on outcomes in surgical patients: A systematic review and meta-analysis
2018 · A.C. Panayi, A.R. Orkaby, et al. · The American Journal of Surgery · 418
Year
Topic