Feature selection of DNA methylation biosignatures for neuropathy with comorbid drug abuse in the setting of HIV infection
Description: Distal sensory polyneuropathy and substance use disorder are common in the HIV-infected population and can impact immune resilience and HIV outcomes. Applying a combination of epigenome-wide association and machine learning approaches, we aim to identify a panel of DNA methylation features in white blood cells for HIV-associated distal sensory polyneuropathy and substance misuse that link to immune resilience, HIV frailty and mortality. The selected features can serve as biomarker for neuropathy and enhance our understanding of the interplay between neuropathy and substance misuse in HIV-infected population.
Funder: National Institute on Drug Abuse
Funding type: research
Funder scheme: R01
Start date: 2018-09-15
End date: 2025-05-31
Investigator: BRADLEY E AOUIZERAT
Institution: YALE UNIVERSITY
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Funded outputs count: 36
Funder award ID: R01DA047820
OpenAlex ID: G299262383