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Theranostics of Photoreceptor-RPE-Choroid Neurovascular Unit in Eye Diseases:

Description: Project Narrative This project will investigate novel diagnostic methods and potential treatment in animal models of twp macular degenerations: the RPE mitochondrial dysfunction model, and the Doyne Honeycomb Retinal Dystrophy model. As a result of this proposal, novel optical methods will be available for translation to diagnose retinal degenerations in human patients, including inherited and age-related macular degeneration (AMD). This study will also continue to lay a foundation for novel locally, light-activated drug delivery in human ocular disease.
Funding type: research
Funder scheme: R01
Start date: 2017-02-01
End date: 2027-02-28
Investigator: ROBERT J ZAWADZKI
Institution: UNIVERSITY OF CALIFORNIA AT DAVIS
Funded outputs count: 46
Funder award ID: R01EY026556
OpenAlex ID: G9000895748
Retinal Layer Changes With Aging and Cognitive Decline in Rhesus Macaques
2026 · Yin Allison Liu, Mrinal Prabhakar, et al. · Translational Vision Science & Technology
Subretinal Aspects of the Optoretinographic Response
2026 · Reddikumar Maddipatla, Maciej M. Bartuzel, et al. · Investigative Ophthalmology & Visual Science
Dark adaptation of cone photoreceptor responses is revealed by optoretinography
2026 · Yao Cai, Anqi Zhang, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Phase-based optoretinographic measurements of cones with a raster-scanning adaptive optics OCT are highly repeatable
2026 · Yao Cai, Maciej M. Bartuzel, et al. · Biomedical Optics Express · 2
Factors Associated with Machine Learning–Based Predictions of Retinal Aging Using Teleretinal Screening Images from Patients with Diabetes
2026 · Tuyet Thao Nguyen, Maria Jessica Cruz, et al. · Ophthalmology Science · 1
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Combined Mouse Retinal Optoretinography/Electroretinography System to Study Light-Evoked Responses in Animal Models of Retinal Degeneration
2026 · Hang Chan Jo, Ewelina A. Pijewska, et al. · Investigative Ophthalmology & Visual Science · 3
Deep reinforcement learning for automatic defocus correction using OCT image intensity
2025 · Guozheng Xu, Thomas J. Smart, et al. · Biomedical Optics Express · 1
Insight into human photoreceptor function: Modeling optoretinographic responses to diverse stimuli
2025 · Denise Valente, Kari V. Vienola, et al. · Science Advances · 10
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Genotype Prediction from Retinal Fundus Images Using Deep Learning in Eyes with Age-Related Macular Degeneration
2025 · Avishai Halev, Denis Huang, et al. · Ophthalmology Science
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A Narrowband 635 nm Autofluorescence Peak in Albino Mouse Eyes Found With Multi-Modal Imaging Reveals the Presence of Protoporphyrin IX in the Choroid
2025 · Pengfei Zhang, Suman K. Manna, et al. · Investigative Ophthalmology & Visual Science · 2
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Whole retina light-evoked optoretinography (ORG) under different retina hydration levels: modeling of Bruch’s membrane ORGs
2025 · Pengfei Zhang, Sarah J. Karlen, et al. · Biomedical Optics Express · 10
On-axis full-field swept-source optical coherence tomography for murine retinal imaging
2024 · Ratheesh K. Meleppat, Denise Valente, et al. · Optics Letters · 26
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Evaluating the performance of OCT in assessing static and potential dynamic properties of the retinal ganglion cells and nerve fiber bundles in the living mouse eye
2023 · Pengfei Zhang, Olga Vafaeva, et al. · Biomedical Optics Express · 7
Adaptive optics scanning laser ophthalmoscopy and optical coherence tomography (AO-SLO-OCT) system for in vivo mouse retina imaging
2022 · Pengfei Zhang, Daniel J. Wahl, et al. · Biomedical Optics Express · 23
Velocity-based optoretinography for clinical applications
2022 · Kari V. Vienola, Denise Valente, et al. · Optica · 42
In Vivo Imaging of Retinal and Choroidal Morphology and Vascular Plexuses of Vertebrates Using Swept-Source Optical Coherence Tomography
2022 · Ratheesh K. Meleppat, Christopher R. Fortenbach, et al. · Translational Vision Science & Technology · 45
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CRISPR-based VEGF suppression using paired guide RNAs for treatment of choroidal neovascularization
2022 · Sook Hyun Chung, Tzu-Ni Sin, et al. · Molecular Therapy — Nucleic Acids · 37
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Volumetric data analysis enabled spatially resolved optoretinogram to measure the functional signals in the living retina
2021 · Lijie Zhang, Rongyao Dong, et al. · Journal of Biophotonics · 14
Extraction of phase-based optoretinograms (ORG) from serial B-scans acquired over tens of seconds by mouse retinal raster scanning OCT system
2021 · Ewelina Pijewska, Pengfei Zhang, et al. · Biomedical Optics Express · 31
Simultaneous directional full-field OCT using path-length and carrier multiplexing
2021 · Denise Valente, Kari V. Vienola, et al. · Optics Express · 5
In vivo multimodal retinal imaging of disease-related pigmentary changes in retinal pigment epithelium
2021 · Ratheesh K. Meleppat, Kaitryn E. Ronning, et al. · Scientific Reports · 63
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Animal models of diabetic retinopathy
2021 · Jose Quiroz, Amirfarbod Yazdanyar · Annals of Translational Medicine · 55
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In vivo Morphometry of Inner Plexiform Layer (IPL) Stratification in the Human Retina With Visible Light Optical Coherence Tomography
2021 · Tingwei Zhang, Aaron M. Kho, et al. · Frontiers in Cellular Neuroscience · 31
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In Situ Morphologic and Spectral Characterization of Retinal Pigment Epithelium Organelles in Mice Using Multicolor Confocal Fluorescence Imaging
2020 · Ratheesh K. Meleppat, Kaitryn E. Ronning, et al. · Investigative Ophthalmology & Visual Science · 31
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Visible light OCT improves imaging through a highly scattering retinal pigment epithelial wall
2020 · Tingwei Zhang, Aaron M. Kho, et al. · Optics Letters · 21
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