The relationship between aging and cancer revealed by the mechanism of McSC fate determination
Description: Tissue stem cells play important roles in tissue homeostasis, aging and cancer, yet it is not clear how stem cells govern the different tissue fates. Hair graying and hair loss are known as the typical aging phenotypes. Hair graying is caused by the exhaustion of McSCs, while melanoma develops due to abnormal proliferation of McSCs. In this study, using skin as a model, McSC niche has been clarified to have a significant impact on the tissue fate of hair graying and melanoma under aging and genomic stress.
Amount: ¥4,290,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2018-04-01
End date: 2022-03-31
Investigator: Yasuaki Mohri
Institution: The University of Tokyo(2021)Tokyo Medical and Dental University(2018-2020)
Funded outputs count: 4
Funder award ID: 18K15114
OpenAlex ID: G3531492293