Award

National Neurological Aids Bank

Description: Project Narrative In order to cure CNS HIV infection and to elucidate the mechanisms of HIV neuropathogenesis under ART, investigators require a reliable source of annotated human tissues, fluids, and data. The National Neurological AIDS Bank (NNAB) has supplied these resources for 2 decades and will continue to do so in the future.

Funder: National Institute of Mental Health

Funding type: cooperative_agreement

Funder scheme: U24

Start date: 2013-05-10

End date: 2024-04-30

Investigator: ELYSE J SINGER

Institution: UNIVERSITY OF CALIFORNIA LOS ANGELES

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

Funded outputs count: 229

Funder award ID: U24MH100929

OpenAlex ID: G727350137

SIV/HIV Induces Arachidonic Acid–Mediated Inflammation in the Heart by a Pannexin-1 Mechanism

2026 · David Ajasin, Shelby Devin, et al. · American Journal Of Pathology

Central nervous system B cell multiomics reveals a legacy of immune dysregulation in long-term treated HIV infection

2026 · Paraskevas Filippidis, Chang Lu, et al. · Science Advances

Cross-Compartment Virome Profiling in Human Immunodeficiency Virus Infection and Substance Use Disorder Reveals Brain–CSF–Periphery Discordance and Hepatitis B Virus in Central Nervous System

2026 · Xin Dang, Barbara A. Hanson, et al. · International Journal of Molecular Sciences

VEGF Is a Stronger Predictor of Depressive Symptoms than Other Inflammation Markers in People with HIV on Antiretroviral Therapy

2026 · Dana Gabuzda, Jun Yin, et al. · Viruses

Predictive Utility of ViroFind Detection of Blood and CSF Virome for Viral Presence in Human Brain Tissue

2026 · Xin Dang, Barbara A. Hanson, et al. · International Journal of Molecular Sciences

HIV heart inflammation is mediated by HIV infected myeloid cells, HIV-tat secretion, and aberrant function of Connexin43-containing channels

2026 · David Ajasin, Sophia Arredondo-Anez, et al. · Scientific Reports · 3

Latent HIV Infection of BBB Pericytes Enhances Gap Junction-mediated Crosstalk with Endothelial Cells

2026 · Sarah Schmidlin, Oandy Naranjo, et al. · Molecular Neurobiology

International application of an optimized harmonization approach for longitudinal cognitive data in people with HIV

2025 · Lang Lang, Leah H. Rubin, et al. · Journal of Clinical Epidemiology

Persistent type I interferon signaling within the brain of people with HIV on ART with cognitive impairment

2025 · Yuyang Tang, Ling Xie, et al. · PLoS Pathogens · 11

Neuroinflammation associated with proviral DNA persists in the brain of virally suppressed people with HIV

2025 · Sarah J. Byrnes, Janna Jamal Eddine, et al. · Frontiers in Immunology · 21

Predicting Trajectories of Everyday Functioning in Adults Aging with HIV Using Latent Growth Mixture Modeling

2025 · Lillian Ham, Scott Roesch, et al. · AIDS and Behavior · 1

Multi-omic Characterization of HIV Effects at Single Cell Level across Human Brain Regions

2025 · Junchen Yang, Kriti Agrawal, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 9

Cannabis use is associated with a lower likelihood of presence of HIV drug resistance mutations in a retrospective cohort of adults with HIV

2025 · Jonathan F. Hale, Shellynea Reynolds, et al. · NeuroImmune Pharmacology and Therapeutics

Brain RNA profiling highlights multiple disease pathways in persons with HIV-associated neurocognitive disorder

2025 · William G. Branton, Na Zhang, et al. · AIDS · 2

Development of a refined harmonization approach for longitudinal cognitive data in people with HIV

2024 · Lang Lang, Leah H. Rubin, et al. · Journal of Clinical Epidemiology · 1

Analysis of MicroRNA Cargo in Circulating Extracellular Vesicles from HIV-Infected Individuals with Pulmonary Hypertension

2024 · Aatish Mahajan, Sumedha Gunewardena, et al. · Cells · 3

Characterization of the brain virome in human immunodeficiency virus infection and substance use disorder

2024 · Xin Dang, Barbara A. Hanson, et al. · PLoS ONE · 9

HIV and COVID-19: two pandemics with significant (but different) central nervous system complications

2024 · Magaki, Shino, Zhang, Ting, et al. · Free Neuropathology · 2

CSF Extracellular Vesicle Aβ42 and Tau/Aβ42 Ratio Are Associated with Cognitive Impairment in Older People with HIV

2023 · Debjani Guha, Vikas Misra, et al. · Viruses · 10

Caspase cleavage of gasdermin E causes neuronal pyroptosis in HIV-associated neurocognitive disorder

2023 · Jason P Fernandes, William G Branton, et al. · Brain · 29

The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency

2023 · Hannah S. Sperber, Kyle A. Raymond, et al. · Cell Reports · 23

Reversal of biological age in multiple rat organs by young porcine plasma fraction

2023 · Steve Horvath, Kavita Singh, et al. · GeroScience · 33

CSF Inflammation Markers Associated with Asymptomatic Viral Escape in Cerebrospinal Fluid of HIV-Positive Individuals on Antiretroviral Therapy

2023 · Debjani Guha, Vikas Misra, et al. · Viruses · 23

Vascular injury markers associated with cognitive impairment in people with HIV on suppressive antiretroviral therapy

2023 · Debjani Guha, Vikas Misra, et al. · AIDS · 28

Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV

2023 · Thomas A. Angelovich, Catherine R. Cochrane, et al. · Annals of Neurology · 33