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Association Analysis of SNPs in Longevity Assurance Genes

Funding type: research
Funder scheme: R01
Start date: 2004-09-30
End date: 2012-06-30
Investigator: YOUSIN SUH
Institution: ALBERT EINSTEIN COLLEGE OF MEDICINE
Funded outputs count: 33
Funder award ID: R01AG024391
OpenAlex ID: G3901947000
Genome integrity as a potential index of longevity in Ashkenazi Centenarian’s families
2024 · Mariana Andrawus, Gil Ben David, et al. · GeroScience · 9
Effective discovery of rare variants by pooled target capture sequencing: A comparative analysis with individually indexed target capture sequencing
2018 · Seungjin Ryu, Jeehae Han, et al. · Mutation research. Fundamental and molecular mechanisms of mutagenesis · 25
Genetic landscape of APOE in human longevity revealed by high-throughput sequencing
2016 · Seungjin Ryu, Gil Atzmon, et al. · Mechanisms of Ageing and Development · 45
Positive attitude toward life, emotional expression, self-rated health, and depressive symptoms among centenarians and near-centenarians
2015 · Kaori Kato, Richard Zweig, et al. · Aging & Mental Health · 71
MicroRNA transcriptome analysis identifies miR-365 as a novel negative regulator of cell proliferation in Zmpste24-deficient mouse embryonic fibroblasts
2015 · Xing-dong Xiong, Hwa Jin Jung, et al. · Mutation research. Fundamental and molecular mechanisms of mutagenesis · 13
Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage
2015 · Caroline Park, Yousin Suh, et al. · Nature Communications · 224
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An epigenomic role of Fe65 in the cellular response to DNA damage
2015 · Seungjin Ryu, Francesca Teles, et al. · Mutation research. Fundamental and molecular mechanisms of mutagenesis · 8
Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism
2014 · Siyoung Cho, Miook Cho, et al. · Oncotarget · 44
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Genetic variation in Sirtuin 1 (SIRT1) is associated with lipid profiles but not with longevity in Ashkenazi Jews
2014 · Jeehae Han, Gil Atzmon, et al. · Translational research · 14
Deficient Chaperone-Mediated Autophagy in Liver Leads to Metabolic Dysregulation
2014 · Jaime L. Schneider, Yousin Suh, et al. · Cell Metabolism · 340
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A Systematic Review of Innovative Diabetes Care Models in Low-and Middle-Income Countries (LMICs)
2014 · Yonah B. Esterson, Michelle Carey, et al. · Journal of Health Care for the Poor and Underserved · 47
Personality, self-rated health, and cognition in centenarians: Do personality and self-rated health relate to cognitive function in advanced age?
2013 · Kaori Kato, Richard Zweig, et al. · Aging · 28
Identification of a small molecule activator of SIRT1 gene expression
2013 · Si-Young Cho, Miook Cho, et al. · Aging · 28
Genome Instability and Aging
2013 · Jan Vijg, Yousin Suh · Annual Review of Physiology · 379
Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing
2013 · Jeehae Han, Seungjin Ryu, et al. · Mechanisms of Ageing and Development · 23
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in theSIRT1gene
2013 · Jeehae Han, Basil P. Hubbard, et al. · Cell Cycle · 20
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Fatty Acid-Induced Production of Plasminogen Activator Inhibitor-1 by Adipose Macrophages Is Greater in Middle-Aged Versus Younger Adult Participants
2012 · Y. B. Esterson, P. Kishore, et al. · The Journals of Gerontology Series A · 10
MicroRNA in Aging: From Discovery to Biology
2012 · Hwa Jin Jung, Yousin Suh · Current Genomics · 107
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Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing
2012 · Saurabh Gombar, Hwa Jin Jung, et al. · BMC Genomics · 80
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A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci
2012 · Eimear E. Kenny, Itsik Pe'er, et al. · PLoS Genetics · 153
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5-Aza-2′-deoxycytidine-induced genome rearrangements are mediated by DNMT1
2012 · A Y Maslov, M Lee, et al. · Oncogene · 68
Discovery of Functional Gene Variants Associated With Human Longevity: Opportunities and Challenges
2011 · C. Tazearslan, M. Cho, et al. · The Journals of Gerontology Series A · 29
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Lifestyle Factors of People with Exceptional Longevity
2011 · Swapnil N. Rajpathak, Yingheng Liu, et al. · Journal of the American Geriatrics Society · 187
Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles
2011 · Cagdas Tazearslan, Jing Huang, et al. · Aging Cell · 101
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Genetic Studies Reveal the Role of the Endocrine and Metabolic Systems in Aging
2010 · Nir Barzilai, Ilan Gabriely · The Journal of Clinical Endocrinology & Metabolism · 62
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