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氧化还原敏感蛋白senp3介导线粒体融合/分裂失衡参与易损斑块形成的机制研究

Amount: ¥2,980,000
Funding type: research
Funder scheme: 重点项目
Start date: 2018-01-01
End date: 2023-12-31
Investigator: 奔 何
Institution: 上海交通大学
Funded outputs count: 43
Funder award ID: 81830010
OpenAlex ID: G3582356204
Integrated spatial transcriptomics and single-cell RNA sequencing reveal Lars2-mediated spatiotemporal dynamics of myocardial remodeling in a mouse model of transverse aortic constriction
2026 · Hanwen Ni, Feng Liang, et al. · Frontiers in Immunology · 1
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Sentrin‐specific protease 3 (SENP3)-mediated Krüppel-like factor 4 (KLF4) deSUMOylation regulates vascular smooth muscle cell phenotypic switching in atherosclerosis
2025 · Zi Wang, Yinan Wang, et al. · Molecular Biomedicine · 6
Initial Low-Density Lipoprotein Cholesterol and Inflammation Status Predicts Long-Term Mortality in Patients with Acute Coronary Syndrome in the Chinese Population
2025 · Yanqiao Lu, Yujun Sun, et al. · Biomedicines · 1
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Generalized arteriomegaly as a precursor to multifocal aneurysmal disease: implications for early intervention
2025 · Zhaohua Cai, Ben He · Frontiers in Cell and Developmental Biology
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Abdominal aortic aneurysm is a systemic and generalized arteriomegaly in mice and humans
2025 · Zhaohua Cai, Liang Fang, et al. · Scientific Reports · 2
SENP3 Drives Abdominal Aortic Aneurysm Development by Regulating Ferroptosis via De‐SUMOylation of CTH
2025 · Long Chen, Zhaohua Cai, et al. · Advanced Science · 10
NR4A1 deficiency promotes carotid plaque vulnerability by activating integrated stress response via targeting Bcat1
2025 · Long Chen, Yiping Shi, et al. · Cellular and Molecular Life Sciences · 3
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Deletion of MAPL ameliorates septic cardiomyopathy by mitigating mitochondrial dysfunction
2024 · Yinghua Wang, Xiying Huang, et al. · Journal of Translational Medicine · 10
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Endothelial dysfunction: molecular mechanisms and clinical implications
2024 · Xia Wang, Ben He · MedComm · 256
Cellular and molecular characteristics of stromal Lkb1 deficiency‐induced gastrointestinal polyposis based on single‐cell RNA sequencing
2024 · Zhaohua Cai, Yangjing Jiang, et al. · The Journal of Pathology · 7
SUMOylation of TEAD1 Modulates the Mechanism of Pathological Cardiac Hypertrophy
2024 · Xin Shi, Xuening Dang, et al. · Advanced Science · 17
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Assessment of six surrogate insulin resistance indexes for predicting cardiometabolic multimorbidity incidence in Chinese middle‐aged and older populations: Insights from the China health and retirement longitudinal study
2024 · Danrui Xiao, Honglin Sun, et al. · Diabetes/Metabolism Research and Reviews · 79
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Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation
2023 · Yangjing Jiang, Min Liang, et al. · Cellular and Molecular Life Sciences · 15
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Role of Pericytes in Cardiomyopathy-Associated Myocardial Infarction Revealed by Multiple Single-Cell Sequencing Analysis
2023 · Yanqiao Lu, Huanhuan Huo, et al. · Biomedicines · 6
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Post-procedural and long-term functional outcomes of jailed side branches in stented coronary bifurcation lesions assessed with side branch Murray law–based quantitative flow ratio
2023 · Ke Xu, Yue Jiang, et al. · Frontiers in Cardiovascular Medicine · 3
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Smooth Muscle Heterogeneity and Plasticity in Health and Aortic Aneurysmal Disease
2023 · Yunwen Hu, Zhaohua Cai, et al. · International Journal of Molecular Sciences · 42
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Ginsenoside Rb1 Improves Post-Cardiac Arrest Myocardial Stunning and Cerebral Outcomes by Regulating the Keap1/Nrf2 Pathway
2023 · Long Chen, Na Geng, et al. · International Journal of Molecular Sciences · 17
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Jujuboside A attenuates sepsis-induced cardiomyopathy by inhibiting inflammation and regulating autophagy
2022 · Zi Wang, Danrui Xiao, et al. · European Journal of Pharmacology · 24
SENP2 Promotes VSMC Phenotypic Switching via Myocardin De-SUMOylation
2022 · Min Liang, Zhaohua Cai, et al. · International Journal of Molecular Sciences · 16
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Adipose tissue aging: An update on mechanisms and therapeutic strategies
2022 · Zhaohua Cai, Ben He · Metabolism · 24
Congestive heart failure detection based on attention mechanism-enabled bi-directional long short-term memory model in the internet of medical things
2022 · Xin Shi, Xiaobin Zhang, et al. · Journal of Industrial Information Integration · 12
Alprostadil vs. isosorbide dinitrate in ameliorating angina episodes in patients with coronary slow flow phenomenon: A randomized controlled trial
2022 · Weifeng Zhang, Jinjie Dai, et al. · Frontiers in Cardiovascular Medicine
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Primary site as a novel prognostic factor for cardiovascular mortality post-radiotherapy in limited-stage small cell lung cancer: A large population-based study
2022 · Yuwei Zhao, Fen Qin, et al. · Frontiers in Cardiovascular Medicine · 5
Exercise-derived peptide protects against pathological cardiac remodeling
2022 · Anwen Yin, Ruosen Yuan, et al. · EBioMedicine · 33
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New Insights into Adipose Tissue Macrophages in Obesity and Insulin Resistance
2022 · Zhaohua Cai, Yijie Huang, et al. · Cells · 69
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