Mechanistic Assessment of NMES to Rescue Localized Neuromuscular Disruption after ACL Injury
Description: Project Narrative Anterior cruciate ligament tears are a common injury, and in spite of surgical reconstruction and rehabilitation there remain significant impairments in the quadriceps muscle, which contribute to poor long term outcomes. This project has identified a molecular signature of quadriceps neuromuscular dysfunction that contributes to the initial loss of quadriceps muscle strength. An innovative combination of pre-clinical studies and a mechanistic clinical trial will determine the ability of neuromuscular electrical stimulation to mitigate this early molecular signature and restore quadriceps strength.
Funding type: research
Funder scheme: R01
Start date: 2024-08-30
End date: 2029-07-31
Investigator: CHRISTOPHER FRY
Institution: UNIVERSITY OF KENTUCKY
Funded outputs count: 3
Funder award ID: R01AR083375
OpenAlex ID: G9000920435