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Role of p38 MAPK in HSC Self-Renewal and Radiation-Induced Bone Marrow Injury

Funding type: research
Funder scheme: R01
Start date: 2008-09-05
End date: 2014-08-31
Investigator: DAOHONG ZHOU
Institution: UNIV OF ARKANSAS FOR MED SCIS
Funded outputs count: 30
Funder award ID: R01AI080421
OpenAlex ID: G1570410830
The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow
2018 · Lijian Shao, Jianhui Chang, et al. · Nature Communications · 21
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NOS2 deficiency has no influence on the radiosensitivity of the hematopoietic system
2018 · Chengcheng Li, Yi Luo, et al. · Cell & Bioscience · 2
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An oral HemokineTM, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo
2016 · Douglas V. Faller, Serguei A. Castaneda, et al. · Blood Cells Molecules and Diseases · 7
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
2015 · Jianhui Chang, Yingying Wang, et al. · Nature Medicine · 1,819
Granulocyte colony-stimulating factor exacerbates hematopoietic stem cell injury after irradiation
2015 · Chengcheng Li, Lu Lu, et al. · Cell & Bioscience · 54
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IKKβ regulates endothelial thrombomodulin in a Klf2‐dependent manner
2014 · R. Pathak, L. Shao, et al. · Journal of Thrombosis and Haemostasis · 24
Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner
2014 · Lijian Shao, Wei Feng, et al. · Blood · 165
Reactive Oxygen Species in Normal and Tumor Stem Cells
2014 · Daohong Zhou, Lijian Shao, et al. · Advances in cancer research · 403
Hematopoietic Stem Cell Injury Induced by Ionizing Radiation
2013 · Lijian Shao, Yi Luo, et al. · Antioxidants and Redox Signaling · 333
Rapamycin Enhances Long-Term Hematopoietic Reconstitution of Ex Vivo Expanded Mouse Hematopoietic Stem Cells by Inhibiting Senescence
2013 · Yi Luo, Lei Li, et al. · Transplantation · 74
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury.
2013 · Lijian Shao, Yingying Wang, et al. · PubMed · 80
The Effects of p38 MAPK Inhibition Combined with G-CSF Administration on the Hematoimmune System in Mice with Irradiation Injury
2013 · Deguan Li, Yueying Wang, et al. · PLoS ONE · 18
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Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice
2012 · Heng Zhang, Zhibin Zhai, et al. · Free Radical Biology and Medicine · 207
Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity
2012 · Hartmut Geiger, Snehalata A Pawar, et al. · Nature Medicine · 113
A Sensitive and Quantitative Polymerase Chain Reaction-Based Cell Free In Vitro Non-Homologous End Joining Assay for Hematopoietic Stem Cells
2012 · Lijian Shao, Wei Feng, et al. · PLoS ONE · 23
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The glutathione disulfide mimetic NOV-002 inhibits cyclophosphamide-induced hematopoietic and immune suppression by reducing oxidative stress
2012 · C. Marcela Diaz-Montero, Yong Wang, et al. · Free Radical Biology and Medicine · 35
Inhibition of p38 MAPK activity promotes ex vivo expansion of human cord blood hematopoietic stem cells
2012 · Jing Zou, Ping Zou, et al. · Annals of Hematology · 51
Inhibition of p38 MAPK Attenuates Ionizing Radiation-Induced Hematopoietic Cell Senescence and Residual Bone Marrow Injury
2011 · Yong Wang, Lingbo Liu, et al. · Radiation Research · 67
Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKα dependent manner
2011 · Yi Luo, Ping Zou, et al. · Experimental Gerontology · 103
Reactive oxygen species and hematopoietic stem cell senescence
2011 · Lijian Shao, Hongliang Li, et al. · International Journal of Hematology · 198
Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression
2011 · Hongliang Li, Yong Wang, et al. · Free Radical Biology and Medicine · 68
IKKβ Regulates the Repair of DNA Double-Strand Breaks Induced by Ionizing Radiation in MCF-7 Breast Cancer Cells
2011 · Lixian Wu, Lijian Shao, et al. · PLoS ONE · 29
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NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability
2011 · S. K. Pazhanisamy, H. Li, et al. · Mutagenesis · 65
Inhibition of p38 Mitogen-Activated Protein Kinase Promotes Ex Vivo Hematopoietic Stem Cell Expansion
2011 · Yong Wang, Joshua Kellner, et al. · Stem Cells and Development · 70
Mitigation of Ionizing Radiation-induced Bone Marrow Suppression by p38 Inhibition and G-CSF Administration
2011 · Deguan LI, Yueying WANG, et al. · Journal of Radiation Research · 28
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