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Trajectories and modifiable risk factors of brain, gait, and cognitive decline in aging and pre-dementia

Description: PROJECT NARRATIVE: This proposal will be the first to simultaneously examine trajectories, and modifiable risk factors, of structural and functional brain decline, gait decline, and cognitive decline in aging and pre- dementia. This proposal has the potential to directly inform the development of targeted, and appropriately sequenced, interventions for maintaining gait and cognition in aging and pre-dementia.
Funding type: research
Funder scheme: R01
Start date: 2020-06-15
End date: 2026-03-31
Investigator: HELENA M BLUMEN
Institution: ALBERT EINSTEIN COLLEGE OF MEDICINE
Funded outputs count: 30
Funder award ID: R01AG062659
OpenAlex ID: G4831794990
Discovering subtypes with imaging signatures in the Motoric Cognitive Risk Syndrome Consortium using weakly supervised clustering
2025 · Bhargav Teja Nallapu, Ali Ezzati, et al. · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · 1
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Sex-specific brain atrophy patterns associated with the motoric cognitive risk syndrome
2025 · Helena M Blumen, Natalie Delpratt, et al. · Journal of Alzheimer s Disease · 1
Gray Matter Covariance Networks Associated With Parental Longevity—Results From the LonGenity Study
2025 · Natalie Delpratt, Nir Barzilai, et al. · The Journals of Gerontology Series A
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Loneliness and social isolation risk factors in community-dwelling older adults receiving home health services
2025 · Chava Pollak, Yolanda Pham, et al. · BMC Geriatrics · 21
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Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults: Protocol for a Mixed Methods Feasibility Study
2025 · Chava Pollak, Helena M Blumen, et al. · JMIR Research Protocols · 3
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Implementation of a Loneliness Screening and Referral Program in Primary Care: A Mixed Methods Pilot Study
2025 · Chava Pollak, Jennifer Winter, et al. · Research in Gerontological Nursing · 7
Health Outcomes Associated with Loneliness and Social Isolation in Older Adults Living with HIV: A Systematic Review
2024 · Chava Pollak, Kelly Cotton, et al. · AIDS and Behavior · 37
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Distinct Patterns of Brain Atrophy in Amnestic Mild Cognitive Impairment and Motoric Cognitive Risk Syndromes
2024 · Vineela Nagamalla, Joe Verghese, et al. · Neurodegenerative Diseases · 8
White Matter Hyperintensities Are Associated with Slower Gait Speed in Older Adults without Dementia
2024 · Juan P. Vazquez, Joe Verghese, et al. · Neurodegenerative Diseases · 6
Hypothalamic MRI-derived microstructure is associated with neurocognitive aging in humans
2024 · Sandra Aleksic, Roman Fleysher, et al. · Neurobiology of Aging · 5
Cognitive reserve proxies are associated with age-related cognitive decline – Not age-related gait speed decline
2024 · Helena M. Blumen, Oshadi Jayakody, et al. · Neurobiology of Aging · 6
Loneliness predicts decreased physical activity in widowed but not married or unmarried individuals
2024 · Chava Pollak, Joe Verghese, et al. · Frontiers in Public Health · 9
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Linking Dementia Pathology and Alteration in Brain Activation to Complex Daily Functional Decline During the Preclinical Dementia Stages: Protocol for a Prospective Observational Cohort Study
2024 · Pierfilippo De Sanctis, Jeannette R Mahoney, et al. · JMIR Research Protocols · 1
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Loneliness Predicts Progression of Frailty in Married and Widowed, but Not Unmarried Community Dwelling Older Adults
2024 · Chava Pollak, J. Verghese, et al. · The Journal of Frailty & Aging · 12
Difference-Making Pathways to Frailty Through Social Factors: A Configurational Analysis
2023 · Chava Pollak, Joe Verghese, et al. · The Gerontologist · 3
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Longitudinal Associations of Social Support and Gait Speed Decline in Aging
2023 · Chava Pollak, Joe Verghese, et al. · The Journals of Gerontology Series A · 5
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Prodromal Motoric Cognitive Risk Syndrome and Everyday Function
2023 · Nigel L. Kravatz, Dristi Adhikari, et al. · Journal of Alzheimer s Disease · 1
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Loneliness and Functional Decline in Aging: A Systematic Review
2023 · Chava Pollak, Joe Verghese, et al. · Research in Gerontological Nursing · 40
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Age-related changes in gait domains: Results from the LonGenity study
2022 · Oshadi Jayakody, Monique Breslin, et al. · Gait & Posture · 5
Neural signature of mobility-related everyday function in older adults at-risk of cognitive impairment
2022 · Pierfilippo De Sanctis, Johanna Wagner, et al. · Neurobiology of Aging · 11
Longitudinal Associations Between Falls and Risk of Gait Decline: Results From the Central Control of Mobility and Aging Study
2022 · Oshadi Jayakody, Helena M. Blumen, et al. · Archives of Physical Medicine and Rehabilitation · 9
Spatial Navigation and Dementia
2022 · Joe Verghese, Helena M. Blumen · Neurology
Gait in cerebral small vessel disease, pre-dementia, and dementia: A systematic review
2022 · Helena M Blumen, Oshadi Jayakody, et al. · International Journal of Stroke · 44
Increased Social Support Reduces the Incidence of Motoric Cognitive Risk Syndrome
2022 · Nicole Felix, Emmeline Ayers, et al. · Innovation in Aging · 18
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Risk factors for decline in gait speed during walking while talking in older adults
2022 · Oshadi Jayakody, Helena M. Blumen, et al. · Gait & Posture · 11
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