Isomerization of Aspartate residue as a new indicator of aging
Description: The purpose of this study is to define the spontaneous chemical alterations (Asp isomerization) of aspartic acid residues in proteins as a new aging index for proteins containing them. Asp residue in protein is isomerized during life. Along with this, isomerized Asp causes structural changes in proteins including itself, and may cause the onset of age-related diseases (cataract, Alzheimer's disease, etc.). Therefore, quantitative analysis of isomerized Asp in proteins may lead to early detection of diseases. In this study, we succeeded in developing a method for finding a very small amount of isomerized Asp present in the protein, and also succeeded in demonstrating the importance of the site where isomerization was observed.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2017-04-01
End date: 2021-03-31
Investigator: Takumi Takata
Institution: Kyoto University
Funded outputs count: 13
Funder award ID: 17K13221
OpenAlex ID: G3632189461