Pathogenesis of retinal vein occlusion (RVO)
Description: Retinal vein occlusion (RVO) is one of the most common retinal vascular diseases and can seriously threaten vision. However, the mechanisms leading to RVO are still unclear. We finally demonstrated in rats that systemically injected endothelin-1 (ET-1) indeed leads to local constriction of retinal veins and decreases chorioretinal blood flow (Kida et al. Exp. Eye Res 2018).As venous outflow resistance increases (due to constriction of the vein), retinal venous pressure (RVP) also increases. We assume that very high RVP can lead to RVO. In our study, RVP was elevated in both CRVO and BRVO, and furthermore, the elevated RVP was reduced after anti-VEGF therapy in patients with RVO-related macular edema (Kida et al. Graefes Arch Clin Exp Ophthalmol 2021). This suggests that anti-VEGF drugs can reduce the elevated RVP in RVO, and that lowering the high RVP is important for the treatment of RVO with macular edema.
Amount: ¥4,290,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2024-03-31
Investigator: Teruyo Kida
Institution: Osaka Medical and Pharmaceutical University
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 25
Funder award ID: 18K09428
OpenAlex ID: G365674594