Unbiased identification of interventions that extend lifespan
Description: PROJECT NARRATIVE Targeting the aging process may help delay the onset of many age-related chronic diseases. No such longevity interventions are currently known for humans, but lifespan can be extended in all major models organisms. In order to develop interventions for human use, it is important to first identify and characterize them in closely related model organisms. We propose to carry out unbiased identification and characterization of many pharmacological interventions that slow down the aging process and increase lifespan of mice, providing the foundation for their future tests in humans.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2019-09-30
End date: 2025-05-31
Investigator: VADIM N. GLADYSHEV
Institution: BRIGHAM AND WOMEN'S HOSPITAL
Subfield: Aging
Domain: Life Sciences
Funded outputs count: 31
Funder award ID: R01AG067782
OpenAlex ID: G1985713069