Award

2020YFA0803602

Funder: National Key Research and Development Program of China

Funded outputs count: 14

Funder award ID: 2020YFA0803602

OpenAlex ID: G3658372193

Mitochondrial SUMOylation of NDUFA9 drives ClpP-dependent degradation and complex I dysfunction in a Leigh syndrome–associated mutation

2026 · Jiaqian Feng, Xueran Kang, et al. · Nature Communications

A reduction in A-to-I RNA editing by ADAR disrupts Pumilio-mediated inhibition of MAPK signaling to drive intestinal stem cell aging

2026 · Qian Zhang, Yuedan Zhu, et al. · Science Signaling

SUMOylation-deficient TRPV1 in sensory neurons confers resistance to high-fat diet-induced obesity via enhanced sympathetic adipose innervation

2026 · Xiaokun Gu, Weiji Weng, et al. · Journal of Advanced Research · 1

Aging-related peroxisomal dysregulation disrupts intestinal stem cell differentiation through alterations of very long-chain fatty acid oxidation

2025 · Xiaoxin Guo, Gang Du, et al. · PLoS Biology · 1

N-terminal α-amino SUMOylation promotes phosphorylation-independent cofilin-1 translocation to the mitochondrial matrix and induces apoptosis

2025 · Qi Deng, Xiaokun Gu, et al. · Nature Communications · 2

Asparagine prevents intestinal stem cell aging via the autophagy‐lysosomal pathway

2024 · Ting Luo, Liusha Zhao, et al. · Aging Cell · 21

Kaempferol enhances intestinal repair and inhibits the hyperproliferation of aging intestinal stem cells in Drosophila

2024 · Liusha Zhao, Ting Luo, et al. · Frontiers in Cell and Developmental Biology · 12

Vitamin B12 ameliorates gut epithelial injury via modulating the HIF-1 pathway and gut microbiota

2024 · Chenxi Feng, Jinhua Yan, et al. · Cellular and Molecular Life Sciences · 17

Natural flavonoid glycosides Chrysosplenosides I & A rejuvenate intestinal stem cell aging via activation of PPARγ signaling

2024 · Jinbao Ye, La Yan, et al. · Life Medicine · 8

Adar Regulates Drosophila melanogaster Spermatogenesis via Modulation of BMP Signaling

2024 · Qian Zhang, Xinxin Fan, et al. · International Journal of Molecular Sciences · 3

hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA

2023 · Qiao Zhang, Weiji Weng, et al. · Cell Reports · 14

N-terminal α-amino SUMOylation of cofilin-1 is critical for its regulation of actin depolymerization

2023 · Weiji Weng, Xiaokun Gu, et al. · Nature Communications · 24

Sleep loss impairs intestinal stem cell function and gut homeostasis through the modulation of the GABA signalling pathway in Drosophila

2023 · Juanyu Zhou, Li He, et al. · Cell Proliferation · 19

TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors

2022 · Yingwei Gao, Ruining Ma, et al. · Cell Reports · 29