Modeling Maternal Aging Effects That Cause Congenital Anomalies Using Small Fish
Description: In this study, we considered maternal age as one of the environmental factors that cause congenital abnormalities and aimed to elucidate its effects at the molecular level by developing new models. As a result, we developed an experimental model to systematically analyze the effects of maternal age on embryonic development using zebrafish and Xenopus tropicalis as model vertebrates. We also found that embryos from X. tropicalis females of unsuitable age showed severe developmental abnormalities and identified associated gene and protein expression changes.
Amount: ¥6,240,000
Funding type: research
Funder scheme: Grant-in-Aid for Challenging Research (Exploratory)
Start date: 2018-06-29
End date: 2023-03-31
Investigator: Makoto Suzuki
Institution: Hiroshima University(2019-2022)National Institute for Basic Biology(2018)
Funded outputs count: 11
Funder award ID: 18K19351
OpenAlex ID: G3661749820