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Training Program in Precision Genetics of Aging, Alzheimer's Disease and Related Dementias

Description: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH The genetic basis for normal mammalian aging and age-related disease is still largely unexplored. Continued multidisciplinary, rigorous and creative training of the next generation of scientists is necessary for the biomedical and scientific community to develop therapies and interventions for the growing aging population and the increase in Alzheimer's disease incidence.
Funding type: training
Funder scheme: T32
Start date: 2020-05-01
End date: 2026-04-30
Investigator: GARETH R HOWELL
Institution: JACKSON LABORATORY
Funded outputs count: 25
Funder award ID: T32AG062409
OpenAlex ID: G5251458435
CMV-specific clonal expansion in human Th1 and GZMK⁺ CD8⁺ T cells
2026 · Titas Grabauskas, Luke Trinity, et al. · Genome biology · 2
Adoption of MMPose, a general purpose pose estimation library, for animal tracking
2026 · Jessica D. Choi, Vivek Kumar · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Optimizing Intermediate Representations: A Framework for Low-Cost, High-Accuracy Behavior Quantification
2026 · Jessica D. Choi, Brian Geuther, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Spoti-find: a novel, open-source void spot assay image analysis tool
2026 · Cara C. Hardy, Susan Sheehan, et al. · American Journal of Physiology-Renal Physiology
CMV-specific clonal expansion of Th1, GZMK⁺ CD8⁺, and TEMRA T cells revealed by human PBMC single cell profiling
2025 · Titas Grabauskas, Luke Trinity, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 3
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Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer
2024 · Brittany L. Angarola, Siddhartha Sharma, et al. · Nature Aging · 54
Proteins required for stereocilia elongation during mammalian hair cell development ensure precise and steady heights during adult life
2024 · Elli I. Hartig, Matthew Day, et al. · Proceedings of the National Academy of Sciences · 6
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Detecting the effect of genetic diversity on brain composition in an Alzheimer’s disease mouse model
2024 · Brianna Gurdon, Sharon C. Yates, et al. · Communications Biology · 15
Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti–PD-1 Immune Checkpoint Inhibitor Cancer Therapy
2024 · Jeremy J Racine, John F Bachman, et al. · The Journal of Immunology · 17
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New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop
2024 · Maria A. Telpoukhovskaia, Thomas J. Murdy, et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 3
Genetic context drives age‐related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits
2023 · Sarah E. Heuer, Emily W. Nickerson, et al. · Aging Cell · 8
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Comprehensive single cell aging atlas of mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer
2023 · Brittany L. Angarola, Siddhartha Sharma, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
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Control of hippocampal synaptic plasticity by microglia–dendrite interactions depends on genetic context in mouse models of Alzheimer's disease
2023 · Sarah E. Heuer, Kelly J. Keezer, et al. · Alzheimer s & Dementia · 12
Aging and urinary control: Alterations in the brain–bladder axis
2023 · Cara C. Hardy, Ron Korstanje · Aging Cell · 25
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Genetic context controls early microglia-synaptic interactions in mouse models of Alzheimer’s disease
2023 · Sarah E. Heuer, Kelly J. Keezer, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 3
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MYC regulates a pan-cancer network of co-expressed oncogenic splicing factors
2022 · Laura Urbanski, Mattia Brugiolo, et al. · Cell Reports · 56
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Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a -Mutant Clonal Hematopoiesis
2022 · Jennifer M. SanMiguel, Elizabeth Eudy, et al. · Cancer Discovery · 97
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The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice
2022 · Alaina M Reagan, Karen E Christensen, et al. · Journal of Cerebral Blood Flow & Metabolism · 21
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Cell origin–dependent cooperativity of mutant Dnmt3a and Npm1 in clonal hematopoiesis and myeloid malignancy
2022 · Jennifer M. SanMiguel, Elizabeth Eudy, et al. · Blood Advances · 20
Genetic control of the pluripotency epigenome determines differentiation bias in mouse embryonic stem cells
2021 · Candice Byers, Catrina Spruce, et al. · The EMBO Journal · 15
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Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation
2021 · Masaru Miyano, Rosalyn W. Sayaman, et al. · Cancer Prevention Research · 19
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Splicing alterations in healthy aging and disease
2021 · Brittany Lynn Angarola, Olga Anczuków · Wiley Interdisciplinary Reviews - RNA · 69
Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis
2020 · Jennifer M. SanMiguel, Kira Young, et al. · Experimental Hematology · 57
Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice
2020 · Sarah E. Heuer, Sarah M. Neuner, et al. · Learning & Memory · 29
2.小学生児童における走り高跳びの指導がもたらす効果(第16回日本体力医学会近畿地方会)
2002 · 佐代子 石川, 寛一 三村, et al. · 体力科學
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