Award

Enriching the Rhode Island Child Health Study

Description: NARRATIVE The Rhode Island Child Health Study (RICHS) cohort provides a unique and innovative birth cohort resource focused on the fundamental role of the placenta in the programming of children's health and disease risk. Infrastructure support for the cohort will allow for further longitudinal assessments that will enable multiple high- impact research projects aimed at early risk assessment and intervention. Infrastructure support will also facilitate broad data sharing of this resource with the scientific community and public.

Funder: National Institute of Environmental Health Sciences

Funding type: research

Funder scheme: R24

Start date: 2017-09-30

End date: 2022-12-22

Investigator: CARMEN JOSEPH MARSIT

Institution: EMORY UNIVERSITY

Funded outputs count: 60

Funder award ID: R24ES028507

OpenAlex ID: G7022195403

Impact of placental and peripheral blood DNA methylation on celiac disease susceptibility

2025 · Alba Hernangomez‐Laderas, Ariadna Cilleros‐Portet, et al. · Journal of Pediatric Gastroenterology and Nutrition

Sex-differentiated placental methylation and gene expression regulation has implications for neonatal traits and adult diseases

2025 · Fasil Tekola-Ayele, Richard J. Biedrzycki, et al. · Nature Communications · 21

Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders

2025 · Ariadna Cilleros-Portet, Corina Lesseur, et al. · Nature Communications · 17

Prenatal Stress and Socioeconomic Status as Predictors of Placental Methylation in Pregnant People

2024 · Czenilriene J. Santander, Sharon Y. Lee, et al. · Merrill-palmer Quarterly · 3

Epigenetic landscape of 5-hydroxymethylcytosine and associations with gene expression in placenta

2024 · Michael Mortillo, Elizabeth M. Kennedy, et al. · Epigenetics · 4

Sex-dependent placental methylation quantitative trait loci provide insight into the prenatal origins of childhood onset traits and conditions

2024 · William Casazza, Amy M. Inkster, et al. · iScience · 4

Placenta DNA methylation levels of the promoter region of the leptin receptor gene are associated with infant cortisol

2023 · Brie M. Reid, Nicki L. Aubuchon-Endsley, et al. · Psychoneuroendocrinology · 9

Select Early-Life Environmental Exposures and DNA Methylation in the Placenta

2022 · Michael Mortillo, Carmen J. Marsit · Current Environmental Health Reports · 41

Placental microRNAs relate to early childhood growth trajectories

2022 · Elizabeth M. Kennedy, Karen Hermetz, et al. · Pediatric Research · 8

Prenatal lead (Pb) exposure is associated with differential placental DNA methylation and hydroxymethylation in a human population

2022 · Pei Wen Tung, Elizabeth M. Kennedy, et al. · Epigenetics · 15

Human placental microRNAs dysregulated by cadmium exposure predict neurobehavioral outcomes at birth

2022 · Jesse M. Tehrani, Elizabeth Kennedy, et al. · Pediatric Research · 12

Variation in placental microRNA expression associates with maternal family history of cardiovascular disease

2022 · Jesse M. Tehrani, Elizabeth M. Kennedy, et al. · Journal of Developmental Origins of Health and Disease · 1

Research Capacity Training on Environmental Health and Noncommunicable Diseases in the Country of Georgia: Challenges and Lessons Learned during the COVID-19 Pandemic

2022 · Carla J. Berg, Lela Sturua, et al. · International Journal of Environmental Research and Public Health · 1

Placental Gene Transcript Proportions are Altered in the Presence of In Utero Arsenic and Cadmium Exposures, Genetic Variants, and Birth Weight Differences

2022 · Maya A. Deyssenroth, Shouneng Peng, et al. · Frontiers in Genetics · 5

Placental multi-omics integration identifies candidate functional genes for birthweight

2022 · Fasil Tekola-Ayele, Xuehuo Zeng, et al. · Nature Communications · 30

PM2.5 exposure during pregnancy is associated with altered placental expression of lipid metabolic genes in a US birth cohort

2022 · Kirtan Kaur, Corina Lesseur, et al. · Environmental Research · 36

Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study

2022 · Pei Wen Tung, Amber Burt, et al. · Environmental Epidemiology · 26

Selenium-associated differentially expressed microRNAs and their targeted mRNAs across the placental genome in two U.S. birth cohorts

2021 · Fu-Ying Tian, Elizabeth M. Kennedy, et al. · Epigenetics · 8

Association between placental toxic metal exposure and NICU Network Neurobehavioral Scales (NNNS) profiles in the Rhode Island Child Health Study (RICHS)

2021 · Pei Wen Tung, Amber Burt, et al. · Environmental Research · 25

Placental gene networks at the interface between maternal PM2.5 exposure early in gestation and reduced infant birthweight

2021 · Maya A. Deyssenroth, Maria José Rosa, et al. · Environmental Research · 36

A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches

2021 · Stephanie H. Parade, Lindsay Huffhines, et al. · Translational Psychiatry · 174

Placental microRNA expression associates with birthweight through control of adipokines: results from two independent cohorts

2020 · Elizabeth M. Kennedy, Karen Hermetz, et al. · Epigenetics · 20

Seasonally variant gene expression in full‐term human placenta

2020 · Danielle A. Clarkson‐Townsend, Elizabeth Kennedy, et al. · The FASEB Journal · 14

Selenium-associated DNA methylation modifications in placenta and neurobehavioral development of newborns: An epigenome-wide study of two U.S. birth cohorts

2020 · Fu-Ying Tian, Todd M. Everson, et al. · Environment International · 40

Associations of maternal diet and placenta leptin methylation

2020 · Teresa E. Daniels, Alexander I. Sadovnikoff, et al. · Molecular and Cellular Endocrinology · 27