Identifying the origins of resilience through human single cell molecular networks, then testing them in diverse, resilient, human IPS lines
Description: PROJECT NARRATIVE Some older individuals have excellent cognitive function despite their brains showing high levels of pathology associated with Alzheimer’s disease. From such individuals, we will learn about the molecular basis of their resilience to Alzheimer’s, and test these predictions in neurons grown from these same brains. These tests will show if we can essentially copy these natural forms of resilience and also provide high-value drug targets.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2018-09-30
End date: 2025-05-31
Investigator: CHRISTOPHER A. GAITERI
Institution: UPSTATE MEDICAL UNIVERSITY
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 20
Funder award ID: R01AG061798
OpenAlex ID: G2702831338