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Nutritional modulation to minimize resistance exercise induced metabolic deregulations and improve training responsiveness in Chronic Obstructive Pulmonary Disease

Description: This study aims at reversing resistance exercise induced metabolic deregulations in patients with Chronic Obstructive Pulmonary Disease and to provide the mechanistic basis for and evaluation of a new targeted nutritional formulation alongside exercise training to improve muscle function and outcomes.
Funding type: research
Funder scheme: R56
Start date: 2019-09-15
End date: 2021-08-31
Investigator: NICOLAAS E DEUTZ
Institution: TEXAS A&M UNIVERSITY
Field: Medicine
Funded outputs count: 65
Funder award ID: R56HL141744
OpenAlex ID: G7236618272
Hypoxia‐inducible factor‐1a (HIF1a) as a context‐dependent integrator of metabolic stress in skeletal muscle
2026 · Nicole Welch, Pugazhendhi Kannan, et al. · The Journal of Physiology
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Voluntary wheel running modulates murine gut microbiome during hyperammonemic stress
2026 · Annette Bellar, Naseer Sangwan, et al. · Microbiology Spectrum · 1
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Urine Proteomic Profiling at Admission Reveals Complement Biomarkers Linked to Alcohol‐Associated Liver Disease
2026 · Luan Prado, Ryan Musich, et al. · Alcoholism Clinical and Experimental Research · 1
Voluntary Activity Wheel Running Improves Hyperammonaemia‐Induced Skeletal Muscle Molecular and Metabolic Perturbations in Mice
2025 · Annette Bellar, Avinash Kumar, et al. · Journal of Cachexia Sarcopenia and Muscle · 3
Biological sex and age‐associated changes in muscle and brain health in Chronic Obstructive Pulmonary Disease: A large cross‐sectional study
2025 · Minchae C. Kang, Nicolaas E. P. Deutz, et al. · Nutrition in Clinical Practice · 6
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Presence of chronic morbidities alters skeletal muscle health and amino acid kinetics in mild cognitive impairment
2025 · Sofie M De Wandel, Nicolaas EP Deutz, et al. · Journal of Alzheimer s Disease · 2
Integrated Multiomics Analyses of the Molecular Landscape of Sarcopenia in Alcohol‐Related Liver Disease
2025 · Nicole Welch, Pugazhendhi Kannan, et al. · Journal of Cachexia Sarcopenia and Muscle · 7
Prolonged disturbances in citrulline metabolism following resistance exercise in COPD
2025 · Tarun Sontam, Nicolaas E.P. Deutz, et al. · Clinical Nutrition · 3
Association of Components of Metabolic Syndrome and the Progression of Nonalcoholic Fatty Liver Disease
2025 · Phuc Le, Moosa Tatar, et al. · The American Journal of Gastroenterology · 8
Prolonged increase in glutamate whole body and intracellular production in older adults with COPD and healthy controls post-resistance exercise
2025 · Robert H. Mbilinyi, Nicolaas E.P. Deutz, et al. · Metabolism · 2
Reviewer #3 (Public review): Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis
2025 · eLife
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Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis
2025 · Adam Kim, Megan R McMullen, et al. · eLife
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The impact of integrated care on clinical outcomes in patients with alcohol-associated liver disease: Early outcomes from a multidisciplinary clinic
2025 · Shreya Sengupta, Akhil Anand, et al. · Hepatology Communications · 15
Attenuating hyperammonemia preserves protein synthesis and muscle mass via restoration of perturbed metabolic pathways in bile duct-ligated rats
2025 · Cristina R. Bosoi, Avinash Kumar, et al. · Metabolic Brain Disease · 6
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Metabolic kinetics and muscle and brain health markers in older adults, and the role of age and presence of chronic morbidities: A large cross-sectional cohort study
2024 · Minchae C. Kang, Nicolaas E.P. Deutz, et al. · Clinical Nutrition · 10
Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis
2024 · Adam Kim, Megan R. McMullen, et al. · eLife · 2
Ammonia transporter RhBG initiates downstream signaling and functional responses by activating NFκB
2024 · Saurabh Mishra, Nicole Welch, et al. · Proceedings of the National Academy of Sciences · 10
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Nocturnal Hypoxemia is Associated with Sarcopenia in Patients with Chronic Obstructive Pulmonary Disease
2024 · Amy H. Attaway, Reena Mehra, et al. · Annals of the American Thoracic Society · 11
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Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia‐inducible factor‐1α in normoxia
2024 · Nicole Welch, Saurabh Mishra, et al. · The Journal of Physiology · 7
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Muscle loss phenotype in COPD is associated with adverse outcomes in the UK Biobank
2024 · Amy H. Attaway, Rocio Lopez, et al. · BMC Pulmonary Medicine · 16
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Reduced plasma glycine concentration in healthy and chronically diseased older adults: a marker of visceral adiposity?
2024 · Lars NJ Deutz, Raven A Wierzchowska-McNew, et al. · American Journal of Clinical Nutrition · 6
Proteomics identifies complement protein signatures in patients with alcohol-associated hepatitis
2024 · Moyinoluwa Taiwo, Emily Huang, et al. · JCI Insight · 11
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Emergency services utilization by patients with alcohol‐associated hepatitis: An analysis of national trends
2024 · Shreya Sengupta, Akhil Anand, et al. · Alcoholism Clinical and Experimental Research · 3
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Using the Electronic Health Record to Develop a Gastric Cancer Risk Prediction Model
2024 · Michelle Kang Kim, Carol Rouphael, et al. · Gastro Hep Advances · 4
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Challenges in and Opportunities for Electronic Health Record-Based Data Analysis and Interpretation
2023 · Michelle Kang Kim, Carol Rouphael, et al. · Gut and Liver · 127
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