Somatic TET2 mutations in cardiac remodeling
Description: NARRATIVE The accumulation of somatic DNA mutations over time is a hallmark of aging in many tissues. However, the causal role of somatic mutations in age-associated disorders other than cancer is a matter of debate, and remains unexplored in the setting of cardiovascular disease, the leading cause of death in elderly individuals. The proposed research seeks to determine if there is a causal connection between relatively common somatic mutations in the hematopoietic system and cardiovascular disease, and to ascertain the potential underlying mechanisms.
Funding type: research
Funder scheme: R01
Start date: 2017-07-15
End date: 2021-06-30
Investigator: KENNETH WALSH
Institution: UNIVERSITY OF VIRGINIA
Funded outputs count: 24
Funder award ID: R01HL138014
OpenAlex ID: G3363365182