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The Role of Leptin in the Maintenance of a Reduced Body Weight

Funding type: research
Funder scheme: R01
Start date: 2008-07-15
End date: 2014-06-30
Investigator: CHRISTOS S MANTZOROS
Institution: BETH ISRAEL DEACONESS MEDICAL CENTER
Funded outputs count: 68
Funder award ID: R01DK079929
OpenAlex ID: G1393442495
Omentin-1 levels are reduced by pharmacologic doses of leptin, but remain unaffected by energy deprivation and display no day–night variation
2014 · O-PR Hamnvik, B Thakkar, et al. · International Journal of Obesity · 19
Circulating alanine transaminase (ALT) and γ-glutamyl transferase (GGT), but not fetuin-A, are associated with metabolic risk factors, at baseline and at two-year follow-up: The prospective Cyprus Metabolism Study
2014 · Xiaowen Liu, Ole-Petter R. Hamnvik, et al. · Metabolism · 41
Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans
2013 · Maria T Vamvini, Konstantinos N Aronis, et al. · European Journal of Endocrinology · 63
Adiponectin and metformin additively attenuate IL1β-induced malignant potential of colon cancer
2013 · Hyun-Seuk Moon, Christos S Mantzoros · Endocrine Related Cancer · 23
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Chemerin is expressed mainly in pancreas and liver, is regulated by energy deprivation, and lacks day/night variation in humans
2013 · John P Chamberland, Reena L Berman, et al. · European Journal of Endocrinology · 39
GLP-1 promotes angiogenesis in human endothelial cells in a dose-dependent manner, through the Akt, Src and PKC pathways
2013 · Konstantinos N. Aronis, John P. Chamberland, et al. · Metabolism · 103
Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines
2013 · Hyun-Seuk Moon, Fadime Dincer, et al. · Metabolism · 203
Gender Dimorphism and Lack of Day/Night Variation or Effects of Energy Deprivation on Undercarboxylated Osteocalcin Levels in Humans
2013 · Joo‐Pin Foo, Konstantinos N. Aronis, et al. · Obesity · 1
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Abdominal Obesity, Independent from Caloric Intake, Accounts for the Development of Intestinal Tumors in Apc1638N/+ Female Mice
2013 · Derek M. Huffman, Leonard H. Augenlicht, et al. · Cancer Prevention Research · 37
Metformin and Sulfonylureas in Relation to Cancer Risk in Type II Diabetes Patients: A Meta-analysis using primary data of published studies
2013 · Bindiya Thakkar, Konstantinos N. Aronis, et al. · Metabolism · 186
Selective capacity of metreleptin administration to reconstitute CD4 + T-cell number in females with acquired hypoleptinemia
2013 · Giuseppe Matarese, Claudia La Rocca, et al. · Proceedings of the National Academy of Sciences · 53
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
2012 · Joo Young Huh, Grigorios Panagiotou, et al. · Metabolism · 1,037
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The Role of Adiponectin in Cancer: A Review of Current Evidence
2012 · Maria Dalamaga, Kalliope N. Diakopoulos, et al. · Endocrine Reviews · 640
Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice
2012 · Hyun-Seuk Moon, Xiaowen Liu, et al. · Gut · 100
Secretion Patterns of Circulating Osteoprotegerin and Response to Acute and Chronic Energy Deprivation in Young Healthy Adults
2012 · Konstantinos N. Aronis, Joo-Pin Foo, et al. · The Journal of Clinical Endocrinology & Metabolism · 1
Variants of the Adiponectin and Adiponectin Receptor-1 Genes and Posttransplantation Diabetes Mellitus in Renal Allograft Recipients
2011 · Eun Seok Kang, Faidon Magkos, et al. · The Journal of Clinical Endocrinology & Metabolism · 24
Amylin and leptin activate overlapping signalling pathways in an additive manner in mouse GT1-7 hypothalamic, C2C12 muscle and AML12 liver cell lines
2011 · H.-S. Moon, J. P. Chamberland, et al. · Diabetologia · 37
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Circulating Adiponectin Is Inversely Associated with Risk of Thyroid Cancer:In Vivoandin VitroStudies
2011 · Nicholas Mitsiades, Kalliopi Pazaitou-Panayiotou, et al. · The Journal of Clinical Endocrinology & Metabolism · 73
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Circulating Clusterin (Apolipoprotein J) Levels Do Not Have Any Day/Night Variability and Are Positively Associated with Total and LDL Cholesterol Levels in Young Healthy Individuals
2011 · Konstantinos N. Aronis, Maria T. Vamvini, et al. · The Journal of Clinical Endocrinology & Metabolism · 8
Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study
2011 · Maria Dalamaga, Sindhu K. Srinivas, et al. · Metabolism · 57
Leptin in human physiology and pathophysiology
2011 · Christos S. Mantzoros, Faidon Magkos, et al. · American Journal of Physiology-Endocrinology and Metabolism · 592
Leptin administered in physiological or pharmacological doses does not regulate circulating angiogenesis factors in humans
2011 · K. N. Aronis, K. N. Diakopoulos, et al. · Diabetologia · 15
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Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance
2011 · Hyun-Seuk Moon, Giuseppe Matarese, et al. · Diabetes · 149
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Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet
2011 · Greeshma K Shetty, Giuseppe Matarese, et al. · European Journal of Endocrinology · 62
Brain responses to food images during the early and late follicular phase of the menstrual cycle in healthy young women: relation to fasting and feeding
2011 · Miguel Alonso-Alonso, Florencia Ziemke, et al. · American Journal of Clinical Nutrition · 58
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