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Epigenetic Regulation of Kir4.1 and GLT1 in Pathophysiology

Description: PUBLIC HEALTH RELEVANCE: Traumatic brain injury is the leading cause of death and disability in children each year in the United States. This proposal seeks to enhance our understanding of the role of astrocytes, the most numerous cells in the brain, in pediatric injury by delineating common mechanisms of astrocytic gene regulation following injury.
Funding type: research
Funder scheme: R01
Start date: 2013-07-01
End date: 2019-04-30
Investigator: MICHELLE L OLSEN
Institution: VIRGINIA POLYTECHNIC INST AND ST UNIV
Funded outputs count: 19
Funder award ID: R01NS075062
OpenAlex ID: G6214048523
K ir 5. 1‐dependent CO 2 /H + ‐sensitive currents contribute to astrocyte heterogeneity across brain regions
2020 · Kelsey C. Patterson, Uri Kahanovitch, et al. · Glia · 19
Isoflurane inhibits a Kir4.1/5.1-like conductance in neonatal rat brainstem astrocytes and recombinant Kir4.1/5.1 channels in a heterologous expression system
2020 · Mengchan Ou, Fu-Shan Kuo, et al. · Journal of Neurophysiology · 10
DNA methylation: A mechanism for sustained alteration of KIR4.1 expression following central nervous system insult
2020 · Jessica L. Boni, Uri Kahanovitch, et al. · Glia · 16
Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1
2019 · Leanne M Holt, Raymundo D Hernandez, et al. · eLife · 172
Magnetic Cell Sorting for In Vivo and In Vitro Astrocyte, Neuron, and Microglia Analysis
2019 · Leanne M. Holt, S. Tristan Stoyanof, et al. · Current Protocols in Neuroscience · 65
AP‐1 and the injury response of theGFAPgene
2018 · Michael Brenner, Albee Messing, et al. · Journal of Neuroscience Research · 20
MeCP2 Deficiency Leads to Loss of Glial Kir4.1
2018 · Uri Kahanovitch, Vishnu A. Cuddapah, et al. · eNeuro · 37
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The α2β2 isoform combination dominates the astrocytic Na+/K+-ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation
2017 · Anca Stoica, Brian Roland Larsen, et al. · Glia · 58
Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus
2017 · Luke T. Stewart, Anas U. Khan, et al. · Journal of Neuroscience · 31
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MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats
2016 · Kelsey C. Patterson, Virginia E. Hawkins, et al. · Human Molecular Genetics · 40
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The role of glial-specific Kir4.1 in normal and pathological states of the CNS
2016 · Sinifunanya E. Nwaobi, Vishnu A. Cuddapah, et al. · Acta Neuropathologica · 255
Novel Applications of Magnetic Cell Sorting to Analyze Cell-Type Specific Gene and Protein Expression in the Central Nervous System
2016 · Leanne Melissa Holt, Michelle Lynne Olsen · PLoS ONE · 82
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New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling
2015 · Michelle L. Olsen, Baljit S. Khakh, et al. · Journal of Neuroscience · 197
MeCP2 in the regulation of neural activity: Rett syndrome pathophysiological perspectives
2015 · Alan Percy, Vishnu Cuddapah, et al. · Degenerative Neurological and Neuromuscular Disease · 7
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Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 (Kir4.1)
2015 · Sinifunanya E. Nwaobi, Michelle L. Olsen · Journal of Visualized Experiments · 10
Elevated GFAP induces astrocyte dysfunction in caudal brain regions: A potential mechanism for hindbrain involved symptoms in type II Alexander disease
2015 · Heather R. Minkel, Tooba Z. Anwer, et al. · Glia · 28
Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia
2014 · Susan L. Campbell, John J. Hablitz, et al. · Frontiers in Cellular Neuroscience · 37
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Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice
2014 · Xiaoping Tong, Yan Ao, et al. · Nature Neuroscience · 590
DNA methylation functions as a critical regulator of Kir4.1 expression during CNS development
2014 · Sinifunanya E. Nwaobi, Erica Lin, et al. · Glia · 56
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