Get started
Award

The gut-brain axis and age-related microglial cell dysfunction

Description: PROJECT NARRATIVE Aging predisposes brain microglia to a pro-inflammatory state that is associated with cognitive and motor impairment, mood disorders, and disability. The goal of the proposed research is to determine the role of the gut-brain axis in regulating age-related changes in microglial cell activity. The long-term goal is to envision a new strategy to prevent or treat unwarranted neuroinflammation in the aged brain.
Funding type: research
Funder scheme: RF1
Start date: 2018-09-01
End date: 2023-08-31
Investigator: RODNEY W JOHNSON
Institution: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
Subfield: Neurology
Funded outputs count: 9
Funder award ID: RF1AG059622
OpenAlex ID: G1395591516
Respiratory infection with influenza A virus delays remyelination and alters oligodendrocyte metabolism
2024 · Allison Y. Louie, Jenny Drnevich, et al. · iScience · 1
The emergence of inflammatory microglia during gut inflammation is not affected by FFAR2 expression in intestinal epithelial cells or peripheral myeloid cells
2024 · Maria Elisa Caetano-Silva, Laurie Rund, et al. · Brain Behavior and Immunity · 21
Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice
2023 · Noah T. Hutchinson, Selena S. Wang, et al. · Experimental Gerontology · 33
Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids
2023 · Maria Elisa Caetano-Silva, Laurie Rund, et al. · Scientific Reports · 224
PDF
Effects of Broad-Spectrum Antibiotic Treatment or Germ-Free Status on Endurance Performance and Exercise Adaptations in Mice
2022 · NOAH T. HUTCHINSON, SELENA S. WANG, et al. · Medicine & Science in Sports & Exercise · 13
Dietary Fiber as a Counterbalance to Age-Related Microglial Cell Dysfunction
2022 · Mario Vailati-Riboni, Laurie Rund, et al. · Frontiers in Nutrition · 32
Treatment With the CSF1R Antagonist GW2580, Sensitizes Microglia to Reactive Oxygen Species
2021 · Katiria Soto-Diaz, Mario Vailati-Riboni, et al. · Frontiers in Immunology · 17
Copper‐Binding Peptides Attenuate Microglia Inflammation through Suppression of NF‐kB Pathway
2021 · Maria Elisa Caetano‐Silva, Laurie A. Rund, et al. · Molecular Nutrition & Food Research · 49
Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice
2018 · Stephanie M. Matt, Jacob M. Allen, et al. · Frontiers in Immunology · 330
PDF
Year
Topic