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Role of anti-aging factor in cellular senescence and physical activity in chronic obstructive pulmonary disease

Description: Cellular senescence is known to be associated with the pathogenesis of chronic obstructive pulmonary disease (COPD). I investigated the relationship between an anti-aging factor, Growth differentiation factor 11 (GDF11) and physical activity in COPD patients. Patients who maintained their plasma level of GDF11 showed higher physical activity and less frequent the acute deterioration of COPD symptoms. GDF11 could be a useful biomarker that reflects the physical activity in COPD.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2018-04-01
End date: 2022-03-31
Investigator: Katsuhiro Onodera
Institution: Tohoku University
Field: Medicine
Funded outputs count: 4
Funder award ID: 18K15916
OpenAlex ID: G3745915602
CYP27A1-27-hydroxycholesterol axis in the respiratory system contributes to house dust mite-induced allergic airway inflammation
2023 · Tatsunori Ito, Tomohiro Ichikawa, et al. · Allergology International · 4
Longitudinal Relationship Between Growth Differentiation Factor 11 and Physical Activity in Chronic Obstructive Pulmonary Disease
2021 · Rie Tanaka, Akira Koarai, et al. · International Journal of COPD · 4
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Nitrosative stress in patients with asthma–chronic obstructive pulmonary disease overlap
2019 · Yorihiko Kyogoku, Hisatoshi Sugiura, et al. · Journal of Allergy and Clinical Immunology · 38
Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease
2018 · Rie Tanaka, Hisatoshi Sugiura, et al. · International Journal of COPD · 15
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