Phase variation of virulence factors in Clostridioides difficile
Description: Project Narrative The proposed research is relevant to the mission of the NIH because it will investigate how Clostridioides difficile, an important human intestinal pathogen, modulates the production of virulence factors during infection. The goals of the project are to identify host cues that affect the virulence phenotypes in C. difficile, to define how C. difficile mediates changes in virulence in response to these cues, and to identify the bacterial factors that drive changes in the phenotypic makeup of a C. difficile population. Understanding how C. difficile regulates virulence factors may reveal new strategies for prevention or treatment of infections.
Funding type: research
Funder scheme: R37
Start date: 2013-05-20
End date: 2029-12-31
Investigator: RITA TAMAYO
Institution: UNIV OF NORTH CAROLINA CHAPEL HILL
Funded outputs count: 27
Funder award ID: R37AI107029
OpenAlex ID: G9000917021