Determining the mechanisms by which calorie restriction alters macrophage polarization to promote an anti-tumor environment in epithelial ovarian cancer
Description: Narrative The proposed research aims to provide a better understanding of the mechanisms by which calorie restriction can impede ovarian cancer progression. Our study will show that calorie restriction can improve anti-tumor immunity by affecting the cellular metabolism of macrophages. This work is directly relevant to public health as the findings of this study will help guide the design of low-cost life-style interventions and precisely targeted therapies for ovarian and other cancers.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 2020-05-01
End date: 2026-04-30
Investigator: RAMANDEEP RATTAN
Institution: HENRY FORD HEALTH SYSTEM
Topic: Dietary Effects on Health
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 5
Funder award ID: R01CA249188
OpenAlex ID: G4660731994