Molecular mechanisms of steroid resistance in severe asthma with obesity
Description: The main aim of this study was to investigate steroid sensitivity of asthmatic patients with obesity and clarify obesity-related factors that modulate steroid sensitivity. The steroid sensitivity in female asthmatic patients with obesity was impaired compared to that in no-obese asthmatic patients. The impaired steroid sensitivity in peripheral blood mononuclear cells (PBMCs) obtained from female asthmatic patients with obesity was restored by metformin, an AMP-activated protein kinase activator. From the result, the obesity-related modulation of AMKP activity potentially involves in the impaired steroid sensitivity in female asthmatic patients with obesity.
Amount: ¥4,550,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: To Masako
Institution: Dokkyo Medical University
Funded outputs count: 8
Funder award ID: 17K09625
OpenAlex ID: G3824383545