Award

Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategies

Description: Narrative: Aging is the number one risk factor for Alzheimer’s disease, heart disease and cancer. Both centenarians and naked mole rats are human and animal models of extreme longevity that delay or escape these aging-related diseases. In combination with recently comprehensive and affordable molecular profiling, these models provide the opportunity to discover biological mechanisms that lead to living longer lives in good health.
Funding type: cooperative_agreement
Funder scheme: UH2
Start date: 2019-09-15
End date: 2022-06-30
Investigator: THOMAS T PERLS
Institution: BOSTON UNIVERSITY MEDICAL CAMPUS
Subfield: Aging
Funded outputs count: 53
Funder award ID: UH2AG064704
OpenAlex ID: G8778549120
2026 · Andrew Chen, Noa Rappaport, et al. · bioRxiv (Cold Spring Harbor Laboratory)
2026 · Stefano Monti, Michael S. Lustgarten, et al. · GeroScience · 3
2026 · Alvin Lu, Liam Kelley, et al. · Journal of The Royal Society Interface · 2
2025 · Paola Sebastiani, Eric Reed, et al. · Advanced Science · 2
2025 · Denis Firsanov, Max Zacher, et al. · Nature · 44
2025 · Qingyan Xiang, Judith J. Lok, et al. · European Journal of Epidemiology · 1
2025 · Devlin C. Moyer, Justin Reimertz, et al. · Trends in biotechnology · 6
2025 · Harold Bae, Zeyuan Song, et al. · GeroScience · 2
2025 · Zeyuan Song, Sophia Gunn, et al. · Frontiers in Systems Biology · 1
2025 · Paola Sebastiani, Eric Reed, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 3
2025 · Fathima Athar, Zhizhong Zheng, et al. · Nature Communications · 24
2025 · Anastasia Gurinovich, Zeyuan Song, et al. · GeroScience · 1
2024 · Alvin Lu, Ilija Dukovski, et al. · bioRxiv (Cold Spring Harbor Laboratory)
2024 · Paola Sebastiani, Stefano Monti, et al. · Cell Reports · 58
2024 · Eric R. Reed, Kevin B. Chandler, et al. · GeroScience · 15
2024 · Michael R. Silverstein, Jennifer M. Bhatnagar, et al. · Nature Ecology & Evolution · 65
2024 · Devlin C. Moyer, Justin Reimertz, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
2023 · Eric Reed, Paola Sebastiani · bioRxiv (Cold Spring Harbor Laboratory) · 2
2023 · Dileep Kishore, Gabriel Birzu, et al. · mSystems · 31
2023 · Tanya T. Karagiannis, Stefano Monti, et al. · Frontiers in Genetics
2023 · Anthony Federico, Joseph Kern, et al. · PLoS Computational Biology · 6
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