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A novel model for DNA damageaccumulation in Alzheimer's disease

Description: In the early stage of Alzheimer's disease, amyloid beta induced DNA damages in neuronal cells, which are repaired by BRCA1. However, these mechanism was deteriorated by BRCA1 co-aggregation with phosphorylated tau in the advanced stage of Alzheimer's disease. We developed a novel model for DNA damage accumulation in neuronal cells. We also developed a method for quantification of DNA damage accumulation using FACS, and analyzed genome-wide distribution of DNA damages and BRCA1 binding regions.
Amount: ¥4,030,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2017-04-01
End date: 2019-03-31
Investigator: Tatsuo Mano
Institution: The University of Tokyo
Funded outputs count: 13
Funder award ID: 17K16113
OpenAlex ID: G3842420844
Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight
2019 · Taro Bannai, Tatsuo Mano, et al. · Scientific Reports · 41
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Lower Serum Calcium as a Potentially Associated Factor for Conversion of Mild Cognitive Impairment to Early Alzheimer’s Disease in the Japanese Alzheimer’s Disease Neuroimaging Initiative
2019 · Kenichiro Sato, Alzheimer’s Disease Neuroimaging Initiative, and Japanese Alzheimer’s Disease Neuroimaging Initiative, et al. · Journal of Alzheimer s Disease · 22
Severe visual impairment and subclinical encephalitis preceding clinical signs of chondritis in relapsing polychondritis
2018 · Ryoji Miyano, Masanori Kurihara, et al. · Neurology and Clinical Neuroscience · 1
Isolated unilateral ptosis due to midbrain infarction
2018 · Masanori Kurihara, Tatsuo Mano, et al. · Neurology and Clinical Neuroscience
An Autopsy Case of Familial Neuronal Intranuclear Inclusion Disease with Dementia and Neuropathy
2018 · Nanaka Yamaguchi, Tatsuo Mano, et al. · Internal Medicine · 24
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Longitudinally extensive vasogenic edema following spinal cord infarction
2018 · Takashi Gondo, Masanori Kurihara, et al. · Neurology and Clinical Neuroscience · 4
Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons
2018 · Takeyuki Tsuchida, Tatsuo Mano, et al. · Brain Research · 11
Ketotic hyperglycemia-related seizure with reversible white matter lesion: Metabolic implication of its reversibility based on magnetic resonance spectroscopy study
2018 · Satoshi Kodama, Tatsuo Mano, et al. · Journal of the Neurological Sciences · 2
DNA methylation level of the neprilysin promoter in Alzheimer's disease brains
2018 · Kenichi Nagata, Tatsuo Mano, et al. · Neuroscience Letters · 19
Case of a 78‐year‐old woman with a neuronal intranuclear inclusion disease
2017 · Hiroshi Takumida, Mitsutaka Yakabe, et al. · Geriatrics and gerontology international/Geriatrics & gerontology international · 8
Degeneration of the Substantia Nigra Following Ipsilateral Striatal Infarction
2017 · Gaku Ohtomo, Tatsuo Mano, et al. · Internal Medicine
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Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease
2017 · Tatsuo Mano, Kenichi Nagata, et al. · Proceedings of the National Academy of Sciences · 101
Tacrolimus-Induced Reversible Cerebral Vasoconstriction Syndrome with Delayed Multi-Segmental Vasoconstriction
2017 · Satoshi Kodama, Tatsuo Mano, et al. · Journal of Stroke and Cerebrovascular Diseases · 22
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