Air Particulate, Metals, and Cognitive Performance in an Aging Cohort- Roles of Circulating Extracellular Vesicles and Non-coding RNAs
Description: PUBLIC HEALTH IMPACT The limited availability of predictors of cognitive decline is a critical gap identified in the 2015 DHHS priorities that, if not addressed soon, will leave the U.S. population unprotected from the current exponential growth of socioeconomic burden from impaired cognition in older individuals. The proposed research will identify novel biomarkers that accurately reflect adverse environmental influences and detect the beginnings of cognitive decline before it manifests fully. Due to the central roles that EVs play in inflammation and tissue signaling, this study could provide a model that can be extended to additional risk factors of cognitive decline, as well as to other chronic diseases of aging.
Funding type: research
Funder scheme: R01
Start date: 2017-09-30
End date: 2023-07-31
Investigator: JOEL D SCHWARTZ
Institution: HARVARD SCHOOL OF PUBLIC HEALTH
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 53
Funder award ID: R01ES027747
OpenAlex ID: G5838693183