Migraine as a Risk Factor for Dementia Onset in the Veterans Health Administration
Description: Despite the high prevalence of both migraine and dementia, there are relatively few studies investigating the association between the two. In particular, the susceptibility of men with migraine to dementia remains comparatively underexplored despite constituting 6% of the US population. The current cohort aims to address gaps in our understanding of the risk of dementia onset conferred by migraine. We aim to evaluate the extent to which migraine is a risk factor for overall and specific dementia onset in men and women, and to investigate moderating factors that may influence the association between migraine and dementia onset in both men and women populations. We will use data from a longitudinal cohort of 241,711 veterans with migraine and their matched controls who presented for care in the Veterans Health Administration. The primary outcome of interest is dementia onset, which is defined as the diagnosis of Alzheimer’s disease, vascular dementia, dementia in other diseases, and unspecified dementia. Secondary outcomes include any underlying physiological conditions of dementia. We will use 3 types of analyses for each aim: survival analysis using Cox proportional hazards regression, logistic regression, and zero-inflated Poisson regression. Analyses will be run both unadjusted and adjusted for relevant covariates. This research will greatly aid in the career development of the fellow in expanding his research knowledge in the field of dementia. The proposed research plan incorporates the fellow’s training objectives through the advanced statistical modelling utilized in the analyses. The fellow will conduct analyses with feedback from the mentors to develop his analytic skills for future research. Lastly, he will gain research management skills through leading this study, which will enrich future research in alignment with the AHA’s mission to promote healthier lives for all.
Funder: American Heart Association
Amount: $33,690
Funding type: training
Funder scheme: Diversity Supplement
Start date: 2024-04-01
End date: 2025-03-31
Investigators: Kensei Maeda, Kensei Maeda
Institution: Yeshiva University
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Funded outputs count: 0
Funder award ID: 24DIVSUP1286771
OpenAlex ID: G3873208806